T-cell surface glycoprotein CD3 zeta chain

BE0003458ProteinHumansCD247

Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. It is acted on by 1 drug in DrugBank.

Gene name
CD247
UniProtKB entry
P20963Swiss-Prot
Cellular location
Cell membrane
Residues / weight
164 residues · 18,696 Da
Also known as
CD3Z · T-cell receptor T3 zeta chain · T3Z · TCRZ

Resolves to

Protein
UniProtP20963UniProt nameCD3Z_HUMAN
Gene
HGNCHGNC:1677NCBI Gene919GeneCardsCD247
Pharmacology
KEGGhsa:919
Structure
PDB1TCEPDB1YGRPDB2HAC
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
Sign in
12Clinical trialsTrials of drugs acting on it, by phase and status
Sign in
8GO termsFunction, process and component, as structured annotations
Sign in
2Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
24+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on T-cell surface glycoprotein CD3 zeta chain, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In