T-cell surface glycoprotein CD3 zeta chain

Details

Name
T-cell surface glycoprotein CD3 zeta chain
Kind
protein
Synonyms
  • CD3Z
  • T-cell receptor T3 zeta chain
  • T3Z
  • TCRZ
Gene Name
CD247
UniProtKB Entry
P20963Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0006729|T-cell surface glycoprotein CD3 zeta chain
MKWKALFTAAILQAQLPITEAQSFGLLDPKLCYLLDGILFIYGVILTALFLRVKFSRSAD
APAYQQGQNQLYNELNLGRREEYDVLDKRRGRDPEMGGKPQRRKNPQEGLYNELQKDKMA
EAYSEIGMKGERRRGKGHDGLYQGLSTATKDTYDALHMQALPPR
Number of residues
164
Molecular Weight
18696.275
Theoretical pI
9.65
GO Classification
Functions
protein heterodimerization activity / protein tyrosine kinase binding
Processes
adaptive immune response / alpha-beta T cell activation / cell surface receptor signaling pathway / Fc-gamma receptor signaling pathway / gamma-delta T cell activation / positive regulation of protein localization to cell surface / protein complex oligomerization / protein-containing complex assembly
Components
Fc-gamma receptor III complex / gamma-delta T cell receptor complex / Golgi apparatus
General Function
Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098, PubMed:1385158, PubMed:1384049, PubMed:7509083). CD3Z ITAMs phosphorylation creates multiple docking sites for the protein kinase ZAP70 leading to ZAP70 phosphorylation and its conversion into a catalytically active enzyme (PubMed:7509083). Plays an important role in intrathymic T-cell differentiation. Additionally, participates in the activity-dependent synapse formation of retinal ganglion cells (RGCs) in both the retina and dorsal lateral geniculate nucleus (dLGN) (By similarity)
Specific Function
identical protein binding
Pfam Domain Function
Signal Regions
1-21
Transmembrane Regions
31-51
Cellular Location
Cell membrane
Gene sequence
>lcl|BSEQ0017108|T-cell surface glycoprotein CD3 zeta chain (CD247)
ATGAAGTGGAAGGCGCTTTTCACCGCGGCCATCCTGCAGGCACAGTTGCCGATTACAGAG
GCACAGAGCTTTGGCCTGCTGGATCCCAAACTCTGCTACCTGCTGGATGGAATCCTCTTC
ATCTATGGTGTCATTCTCACTGCCTTGTTCCTGAGAGTGAAGTTCAGCAGGAGCGCAGAC
GCCCCCGCGTACCAGCAGGGCCAGAACCAGCTCTATAACGAGCTCAATCTAGGACGAAGA
GAGGAGTACGATGTTTTGGACAAGAGACGTGGCCGGGACCCTGAGATGGGGGGAAAGCCG
AGAAGGAAGAACCCTCAGGAAGGCCTGTACAATGAACTGCAGAAAGATAAGATGGCGGAG
GCCTACAGTGAGATTGGGATGAAAGGCGAGCGCCGGAGGGGCAAGGGGCACGATGGCCTT
TACCAGGGTCTCAGTACAGCCACCAAGGACACCTACGACGCCCTTCACATGCAGGCCCTG
CCCCCTCGCTAA
Chromosome Location
1
Locus
1q24.2
External Identifiers
ResourceLink
UniProtKB IDP20963
UniProtKB Entry NameCD3Z_HUMAN
GenBank Gene IDBC025703
GeneCard IDCD247
GenAtlas IDCD247
HGNC IDHGNC:1677
PDB ID(s)1TCE, 1YGR, 2HAC, 2OQ1, 3IK5, 3IOZ, 4XZ1, 6JXR, 7FJD, 7FJE, 7FJF, 7PHR, 8ES7, 8ES8, 8ES9, 8J8I, 8JC0, 8JCB, 8WXE, 8WY0, 8WYI, 8YC0
KEGG IDhsa:919
NCBI Gene ID919
General References
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Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
Muromonabapproved, investigationalyestargetDetails