Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

BE0003477ProteinHumansATP2A2

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen (PubMed:12542527, PubMed:16402920). It is acted on by 3 drugs in DrugBank.

Gene name
ATP2A2
UniProtKB entry
P16615Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
1,042 residues · 114,756 Da
Also known as
7.2.2.10 · ATP2B · Calcium pump 2 · Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform · Endoplasmic reticulum class 1/2 Ca(2+) ATPase

Resolves to

Protein
UniProtP16615UniProt nameAT2A2_HUMAN
Gene
HGNCHGNC:812NCBI Gene488GenBank306850GeneCardsATP2A2
Pharmacology
KEGGhsa:488
Structure
PDB5ZTFPDB6JJUPDB6LLE
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
28GO termsFunction, process and component, as structured annotations
Sign in
5Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
29+ReferencesStructured and connected to the statements they support
Sign in

Which compounds in development act on Sarcoplasmic/endoplasmic reticulum calcium ATPase 2, and which indications are they being tested in?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In