HLA class I histocompatibility antigen, A-3 alpha chain
Details
- Name
- HLA class I histocompatibility antigen, A-3 alpha chain
- Kind
- protein
- Synonyms
- HLAA
- MHC class I antigen A*3
- Gene Name
- HLA-A
- UniProtKB Entry
- P04439Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0012429|HLA class I histocompatibility antigen, A-3 alpha chain MAVMAPRTLLLLLSGALALTQTWAGSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRF DSDAASQRMEPRAPWIEQEGPEYWDQETRNVKAQSQTDRVDLGTLRGYYNQSEAGSHTIQ IMYGCDVGSDGRFLRGYRQDAYDGKDYIALNEDLRSWTAADMAAQITKRKWEAAHEAEQL RAYLDGTCVEWLRRYLENGKETLQRTDPPKTHMTHHPISDHEATLRCWALGFYPAEITLT WQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWEL SSQPTIPIVGIIAGLVLLGAVITGAVVAAVMWRRKSSDRKGGSYTQAASSDSAQGSDVSL TACKV
- Number of residues
- 365
- Molecular Weight
- 40840.41
- Theoretical pI
- 5.85
- GO Classification
- Functionsbeta-2-microglobulin binding / peptide antigen binding / TAP bindingProcessesantigen processing and presentation of exogenous peptide antigen via MHC class I / antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent / antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent / antigen processing and presentation of peptide antigen via MHC class I / cytokine-mediated signaling pathway / immune response / interferon-gamma-mediated signaling pathway / regulation of immune response / type I interferon signaling pathway / viral processComponentscell surface / early endosome membrane / endoplasmic reticulum / ER to Golgi transport vesicle membrane / Golgi apparatus / Golgi membrane / integral component of lumenal side of endoplasmic reticulum membrane / integral component of plasma membrane / membrane / MHC class I protein complex / phagocytic vesicle membrane / plasma membrane
- General Function
- Antigen-presenting major histocompatibility complex class I (MHCI) molecule. In complex with B2M/beta 2 microglobulin displays primarily viral and tumor-derived peptides on antigen-presenting cells for recognition by alpha-beta T cell receptor (TCR) on HLA-A-restricted CD8-positive T cells, guiding antigen-specific T cell immune response to eliminate infected or transformed cells (PubMed:10449296, PubMed:12138174, PubMed:12393434, PubMed:1402688, PubMed:15893615, PubMed:17189421, PubMed:19543285, PubMed:21498667, PubMed:24192765, PubMed:24395804, PubMed:2456340, PubMed:2784196, PubMed:28250417, PubMed:7504010, PubMed:7694806, PubMed:9862734). May also present self-peptides derived from the signal sequence of secreted or membrane proteins, although T cells specific for these peptides are usually inactivated to prevent autoreactivity (PubMed:25880248, PubMed:7506728, PubMed:7679507). Both the peptide and the MHC molecule are recognized by TCR, the peptide is responsible for the fine specificity of antigen recognition and MHC residues account for the MHC restriction of T cells (PubMed:12796775, PubMed:18275829, PubMed:19542454, PubMed:28250417). Typically presents intracellular peptide antigens of 8 to 13 amino acids that arise from cytosolic proteolysis via IFNG-induced immunoproteasome or via endopeptidase IDE/insulin-degrading enzyme (PubMed:17079320, PubMed:17189421, PubMed:20364150, PubMed:26929325, PubMed:27049119). Can bind different peptides containing allele-specific binding motifs, which are mainly defined by anchor residues at position 2 and 9 (PubMed:7504010, PubMed:9862734).
- Specific Function
- beta-2-microglobulin binding
- Pfam Domain Function
- Signal Regions
- 1-24
- Transmembrane Regions
- 309-332
- Cellular Location
- Membrane
- Gene sequence
- Not Available
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P04439 UniProtKB Entry Name 1A03_HUMAN GenBank Gene ID AF226843 GenAtlas ID HLA-A HGNC ID HGNC:4931 PDB ID(s) 2XPG, 3RL1, 3RL2 NCBI Gene ID 3105 - General References
- Strachan T, Sodoyer R, Damotte M, Jordan BR: Complete nucleotide sequence of a functional class I HLA gene, HLA-A3: implications for the evolution of HLA genes. EMBO J. 1984 Apr;3(4):887-94. [Article]
- Cowan EP, Jordan BR, Coligan JE: Molecular cloning and DNA sequence analysis of genes encoding cytotoxic T lymphocyte-defined HLA-A3 subtypes: the E1 subtype. J Immunol. 1985 Oct;135(4):2835-41. [Article]
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- Santos S, Balas A, Garcia-Sanchez F, Lillo R, Merino JL, Vicario JL: Complete cDNA coding sequence of a new HLA-A3 subtype (A*0304) with a new HLA polymorphism at exon 3. Immunogenetics. 1999 Apr;49(4):360-1. [Article]
- Bradshaw D, Gans CP, Jones P, Rizzuto G, Steiner N, Mitton W, Ng J, Koester R, Hartzman RJ, Hurley CK: Novel HLA-A locus alleles including A*01012, A*0306, A*0308, A*2616, A*2617, A*3009, A*3206, A*3403, A*3602 and A*6604. Tissue Antigens. 2002 Apr;59(4):325-7. [Article]
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- McMahon RM, Friis L, Siebold C, Friese MA, Fugger L, Jones EY: Structure of HLA-A*0301 in complex with a peptide of proteolipid protein: insights into the role of HLA-A alleles in susceptibility to multiple sclerosis. Acta Crystallogr D Biol Crystallogr. 2011 May;67(Pt 5):447-54. doi: 10.1107/S0907444911007888. Epub 2011 Apr 13. [Article]
- Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Burckstummer T, Bennett KL, Superti-Furga G, Colinge J: Initial characterization of the human central proteome. BMC Syst Biol. 2011 Jan 26;5:17. doi: 10.1186/1752-0509-5-17. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Nelipepimut-S investigational unknown target Details Coccidioides immitis spherule approved unknown target Details