Collagen alpha-4(IV) chain

BE0003498ProteinHumansCOL4A4

Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. It is acted on by 1 drug in DrugBank.

Gene name
COL4A4
UniProtKB entry
P53420Swiss-Prot
Cellular location
Secreted, extracellular space, extracellular matrix, basement membrane
Residues / weight
1,690 residues · 164,037 Da

Resolves to

Protein
UniProtP53420UniProt nameCO4A4_HUMAN
Gene
HGNCHGNC:2206NCBI Gene1286GeneCardsCOL4A4
Pharmacology
KEGGhsa:1286
Structure
PDB5NB1PDB6WKU
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
Sign in
5GO termsFunction, process and component, as structured annotations
Sign in
2Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
13+ReferencesStructured and connected to the statements they support
Sign in

Which compounds in development act on Collagen alpha-4(IV) chain, and which indications are they being tested in?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In