Guanylyl cyclase C

BE0003502ProteinHumansGUCY2C

Guanylyl cyclase that catalyzes synthesis of cyclic GMP (cGMP) from GTP (PubMed:11950846, PubMed:1718270, PubMed:22436048, PubMed:22521417, PubMed:23269669). It is acted on by 4 drugs in DrugBank.

Gene name
GUCY2C
UniProtKB entry
P25092Swiss-Prot
Cellular location
Cell membrane
Residues / weight
1,073 residues · 123,402 Da
Also known as
4.6.1.2 · GC-C · GUC2C · Heat-stable enterotoxin receptor · hSTAR

Resolves to

Protein
UniProtP25092UniProt nameGUC2C_HUMAN
Gene
HGNCHGNC:4688NCBI Gene2984GeneCardsGUCY2C
Pharmacology
IUPHAR/GtoPdb1750KEGGhsa:2984
Structure
PDB8FX4PDB8GHOPDB8GHP
Drugs

What you can answer from here — as of September 03, 2024

4DrugsApproved to experimental, with action, bond type and pharmacological action
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3Clinical trialsTrials of drugs acting on it, by phase and status
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9GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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26+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Guanylyl cyclase C, how selective are they, and which programs against it are still in active trials?

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