Tumor necrosis factor ligand superfamily member 11

BE0003517ProteinHumansTNFSF11

Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. It is acted on by 5 drugs in DrugBank.

Gene name
TNFSF11
UniProtKB entry
O14788Swiss-Prot
Cellular location
Cell membrane
Residues / weight
317 residues · 35,478 Da
Also known as
ODF · OPGL · Osteoclast differentiation factor · Osteoprotegerin ligand · RANKL

Resolves to

Protein
UniProtO14788UniProt nameTNF11_HUMAN
Gene
HGNCHGNC:11926NCBI Gene8600GeneCardsTNFSF11
Pharmacology
KEGGhsa:8600
Structure
PDB3URFPDB5BNQ
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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11Clinical trialsTrials of drugs acting on it, by phase and status
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19GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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20+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Tumor necrosis factor ligand superfamily member 11, how selective are they, and which programs against it are still in active trials?

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