Aminoglycoside nucleotidyltransferase (4')

BE0003547ProteinStaphylococcus aureusknt

Inactivates the antibiotic kanamycin by catalyzing the transfer of a nucleotidyl group from nucleoside triphosphates such as ATP to the 4'-hydroxyl group of the aminoglycoside. It is acted on by 1 drug in DrugBank.

Gene name
knt
UniProtKB entry
P05057Swiss-Prot
Residues / weight
253 residues · 28,797 Da
Also known as
2.7.7.- · ANT(4') · kan · Kanamycin nucleotidyltransferase · KNTase

Resolves to

Protein
UniProtP05057UniProt nameKANU_STAAU
Gene
NCBI Gene13874812GenBank46496
Pharmacology
KEGGag:AAA88361
Structure
PDB1KANPDB1KNY
Drugs

What you can answer from here — as of June 26, 2025

1DrugApproved to experimental, with action, bond type and pharmacological action
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2GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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8+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Aminoglycoside nucleotidyltransferase (4'), how selective are they, and which programs against it are still in active trials?

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