C-X-C chemokine receptor type 1

BE0003552ProteinHumansCXCR1

Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor (PubMed:1840701). It is acted on by 9 drugs in DrugBank.

Gene name
CXCR1
UniProtKB entry
P25024Swiss-Prot
Cellular location
Cell membrane
Residues / weight
350 residues · 39,791 Da
Also known as
CDw128a · CMKAR1 · CXC-R1 · CXCR-1 · High affinity interleukin-8 receptor A

Resolves to

Protein
UniProtP25024UniProt nameCXCR1_HUMAN
Gene
HGNCHGNC:6026NCBI Gene3577GenBank559050GeneCardsCXCR1
Pharmacology
IUPHAR/GtoPdb68KEGGhsa:3577
Structure
PDB1ILPPDB1ILQPDB2LNL
Drugs

What you can answer from here — as of September 07, 2019

9DrugsApproved to experimental, with action, bond type and pharmacological action
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3Clinical trialsTrials of drugs acting on it, by phase and status
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14GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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32+ReferencesStructured and connected to the statements they support
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Which approved drugs act on C-X-C chemokine receptor type 1, how selective are they, and which programs against it are still in active trials?

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