Acetylserotonin O-methyltransferase

BE0003553ProteinHumansASMT

Catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine). It is acted on by 2 drugs in DrugBank.

Gene name
ASMT
UniProtKB entry
P46597Swiss-Prot
Residues / weight
345 residues · 38,453 Da
Also known as
2.1.1.4 · HIOMT · Hydroxyindole O-methyltransferase

Resolves to

Protein
UniProtP46597UniProt nameASMT_HUMAN
Gene
HGNCHGNC:750NCBI Gene438GenBank607840GeneCardsASMT
Pharmacology
KEGGhsa:438
Structure
PDB4A6DPDB4A6E
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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17+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Acetylserotonin O-methyltransferase, how selective are they, and which programs against it are still in active trials?

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