Nuclear receptor ROR-beta

BE0003554ProteinHumansRORB

Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. It is acted on by 1 drug in DrugBank.

Gene name
RORB
UniProtKB entry
Q92753Swiss-Prot
Cellular location
Nucleus, nucleoplasm
Residues / weight
470 residues · 53,219 Da
Also known as
NR1F2 · Nuclear receptor RZR-beta · Nuclear receptor subfamily 1 group F member 2 · Retinoid-related orphan receptor-beta · RZRB

Resolves to

Protein
UniProtQ92753UniProt nameRORB_HUMAN
Gene
HGNCHGNC:10259NCBI Gene6096GenBank1619294GeneCardsRORB
Pharmacology
IUPHAR/GtoPdb599KEGGhsa:6096
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
Sign in
11GO termsFunction, process and component, as structured annotations
Sign in
2Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
3+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Nuclear receptor ROR-beta, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In