Eosinophil peroxidase

BE0003555ProteinHumansEPX

Heme-containing oxidoreductase that catalyzes the oxidation of small anions, such as nitrite, halides (e.g bromide and chloride (at pH 6.5)) and pseudohalides (e.g thiocyanate) by using hydrogen peroxide to generate the corresponding reactive species hypobromite,... It is acted on by 2 drugs in DrugBank.

Gene name
EPX
UniProtKB entry
P11678Swiss-Prot
Cellular location
Cytoplasmic granule
Residues / weight
715 residues · 81,040 Da
Also known as
1.11.1.7 · EPER · EPO · EPP

Resolves to

Protein
UniProtP11678UniProt namePERE_HUMAN
Gene
HGNCHGNC:3423NCBI Gene8288GenBank31183GeneCardsEPX
Pharmacology
KEGGhsa:8288
Structure
PDB8OGI
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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12+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Eosinophil peroxidase, how selective are they, and which programs against it are still in active trials?

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