Rod cGMP 3',5'-cyclic phosphodiesterase subunit gamma

BE0003556ProteinHumansPDE6G

Inhibitory gamma subunit of the rod-specific cGMP phosphodiesterase (PDE6) complex, which hydrolyzes 3',5'-cyclic GMP in the phototransduction cascade. It is acted on by 4 drugs in DrugBank.

Gene name
PDE6G
UniProtKB entry
P18545Swiss-Prot
Cellular location
Cell projection, cilium, photoreceptor outer segment
Residues / weight
87 residues · 9,643 Da
Also known as
PDEG · Rod GMP-PDE gamma

Resolves to

Protein
UniProtP18545UniProt nameCNRG_HUMAN
Gene
HGNCHGNC:8789NCBI Gene5148GenBank189703GeneCardsPDE6G
Pharmacology
KEGGhsa:5148
Structure
PDB3JWR
Drugs

What you can answer from here — as of June 19, 2026

4DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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14+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Rod cGMP 3',5'-cyclic phosphodiesterase subunit gamma, how selective are they, and which programs against it are still in active trials?

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