Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma

BE0003557ProteinHumansPDE6H

Inhibitory gamma subunit of the cone-specific cGMP phosphodiesterase (PDE6) complex which hydrolyzes 3',5'-cyclic GMP in the phototransduction cascade (By similarity). It is acted on by 2 drugs in DrugBank.

Gene name
PDE6H
UniProtKB entry
Q13956Swiss-Prot
Cellular location
Photoreceptor outer segment membrane
Residues / weight
83 residues · 9,074 Da
Also known as
Cone GMP-PDE gamma

Resolves to

Protein
UniProtQ13956UniProt nameCNCG_HUMAN
Gene
HGNCHGNC:8790NCBI Gene5149GenBank1311544GeneCardsPDE6H
Pharmacology
KEGGhsa:5149
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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7+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma, how selective are they, and which programs against it are still in active trials?

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