Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A

BE0003558ProteinHumansPDE11A

Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP (PubMed:10725373, PubMed:10906126, PubMed:11050148, PubMed:16330539). It is acted on by 1 drug in DrugBank.

Gene name
PDE11A
UniProtKB entry
Q9HCR9Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
933 residues · 104,751 Da
Also known as
3.1.4.35 · 3.1.4.53 · cAMP and cGMP phosphodiesterase 11A

Resolves to

Protein
UniProtQ9HCR9UniProt namePDE11_HUMAN
Gene
HGNCHGNC:8773NCBI Gene50940GenBank10716052GeneCardsPDE11A
Pharmacology
IUPHAR/GtoPdb1311KEGGhsa:50940
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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16+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A, how selective are they, and which programs against it are still in active trials?

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