Prostaglandin reductase 2

BE0003560ProteinHumansPTGR2

Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest activity towards 15-keto-PGE2 (PubMed:19000823). It is acted on by 2 drugs in DrugBank.

Gene name
PTGR2
UniProtKB entry
Q8N8N7Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
351 residues · 38,499 Da
Also known as
1.3.1.48 · 15-oxoprostaglandin 13-reductase · PRG-2 · ZADH1 · Zinc-binding alcohol dehydrogenase domain-containing protein 1

Resolves to

Protein
UniProtQ8N8N7UniProt namePTGR2_HUMAN
Gene
HGNCHGNC:20149NCBI Gene145482GenBank37912002GeneCardsPTGR2
Pharmacology
KEGGhsa:145482
Structure
PDB2VNAPDB2W4QPDB2W98
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
1GO termFunction, process and component, as structured annotations
Sign in
2Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
9+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Prostaglandin reductase 2, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In