Receptor-type tyrosine-protein phosphatase S

BE0003567ProteinHumansPTPRS

Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycan (PubMed:21454754). It is acted on by 2 drugs in DrugBank.

Gene name
PTPRS
UniProtKB entry
Q13332Swiss-Prot
Cellular location
Cell membrane
Residues / weight
1,948 residues · 217,040 Da
Also known as
3.1.3.48 · R-PTP-S · R-PTP-sigma · Receptor-type tyrosine-protein phosphatase sigma

Resolves to

Protein
UniProtQ13332UniProt namePTPRS_HUMAN
Gene
HGNCHGNC:9681NCBI Gene5802GenBank1109792GeneCardsPTPRS
Pharmacology
IUPHAR/GtoPdb1866KEGGhsa:5802
Structure
PDB2FH7PDB2YD2PDB2YD3
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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30GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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18+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Receptor-type tyrosine-protein phosphatase S, how selective are they, and which programs against it are still in active trials?

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