Receptor-type tyrosine-protein phosphatase epsilon

BE0003568ProteinHumansPTPRE

Isoform 1 plays a critical role in signaling transduction pathways and phosphoprotein network topology in red blood cells. It is acted on by 2 drugs in DrugBank.

Gene name
PTPRE
UniProtKB entry
P23469Swiss-Prot
Cellular location
Cell membrane
Residues / weight
700 residues · 80,641 Da
Also known as
3.1.3.48 · Protein-tyrosine phosphatase epsilon · R-PTP-epsilon

Resolves to

Protein
UniProtP23469UniProt namePTPRE_HUMAN
Gene
HGNCHGNC:9669NCBI Gene5791GenBank35792GeneCardsPTPRE
Pharmacology
KEGGhsa:5791
Structure
PDB2JJDPDB6D3FPDB6D4D
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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2GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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14+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Receptor-type tyrosine-protein phosphatase epsilon, how selective are they, and which programs against it are still in active trials?

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