Gamma-aminobutyric acid receptor subunit rho-2

BE0003598ProteinHumansGABRR2

Rho subunit of the pentameric ligand-gated chloride channels responsible for mediating the effects of gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the brain (By similarity). It is acted on by 2 drugs in DrugBank.

Gene name
GABRR2
UniProtKB entry
P28476Swiss-Prot
Cellular location
Postsynaptic cell membrane
Residues / weight
465 residues · 54,150 Da
Also known as
GABA(A) receptor subunit rho-2 · GABA(C) receptor · GABAAR subunit rho-2

Resolves to

Protein
UniProtP28476UniProt nameGBRR2_HUMAN
Gene
HGNCHGNC:4091NCBI Gene2570GenBank456428GeneCardsGABRR2
Pharmacology
KEGGhsa:2570
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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5+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Gamma-aminobutyric acid receptor subunit rho-2, and which indications are they being tested in?

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