Cholesterol transporter ABCA5

BE0003670ProteinHumansABCA5

Cholesterol efflux transporter in macrophages that is responsible for APOAI/high-density lipoproteins (HDL) formation at the plasma membrane under high cholesterol levels and participates in reverse cholesterol transport (PubMed:25125465). It is acted on by 1 drug in DrugBank.

Gene name
ABCA5
UniProtKB entry
Q8WWZ7Swiss-Prot
Cellular location
Golgi apparatus membrane
Residues / weight
1,642 residues · 186,506 Da
Also known as
7.6.2.- · ATP-binding cassette sub-family A member 5 · KIAA1888

Resolves to

Protein
UniProtQ8WWZ7UniProt nameABCA5_HUMAN
Gene
HGNCHGNC:35NCBI Gene23461GenBank17223620GeneCardsABCA5
Pharmacology
KEGGhsa:23461
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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11GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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4+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Cholesterol transporter ABCA5, how selective are they, and which programs against it are still in active trials?

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