Matrix metalloproteinase-20

BE0003696ProteinHumansMMP20

Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). It is acted on by 2 drugs in DrugBank.

Gene name
MMP20
UniProtKB entry
O60882Swiss-Prot
Cellular location
Secreted, extracellular space, extracellular matrix
Residues / weight
483 residues · 54,387 Da
Also known as
3.4.24.- · Enamel metalloproteinase · Enamelysin · MMP-20

Resolves to

Protein
UniProtO60882UniProt nameMMP20_HUMAN
Gene
HGNCHGNC:7167NCBI Gene9313GenBank3005946GeneCardsMMP20
Pharmacology
KEGGhsa:9313
Structure
PDB2JSD
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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1GO termFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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8+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Matrix metalloproteinase-20, and which indications are they being tested in?

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