Tubulin gamma-1 chain

BE0003713ProteinHumansTUBG1

Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685, PubMed:38609661, PubMed:39321809). It is acted on by 1 drug in DrugBank.

Gene name
TUBG1
UniProtKB entry
P23258Swiss-Prot
Cellular location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Residues / weight
451 residues · 51,169 Da
Also known as
Gamma-1-tubulin · Gamma-tubulin complex component 1 · GCP-1 · TUBG

Resolves to

Protein
UniProtP23258UniProt nameTBG1_HUMAN
Gene
HGNCHGNC:12417NCBI Gene7283GenBank183703GeneCardsTUBG1
Pharmacology
KEGGhsa:7283
Structure
PDB1Z5VPDB1Z5WPDB3CB2
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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22GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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14+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Tubulin gamma-1 chain, how selective are they, and which programs against it are still in active trials?

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