High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A

BE0003717ProteinHumansPDE8A

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:18983167). It is acted on by 1 drug in DrugBank.

Gene name: PDE8A
UniProtKB entry: O60658Swiss-Prot
Residues / weight: 829 residues · 93,303 Da
Also known as: 3.1.4.53

Resolves to

Protein

UniProtO60658UniProt namePDE8A_HUMAN

Gene

HGNCHGNC:8793NCBI Gene5151GenBank16417190GeneCardsPDE8A

Pharmacology

IUPHAR/GtoPdb1307KEGGhsa:5151

Structure

PDB3ECMPDB3ECNPDB7CWA

Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action

8GO termsFunction, process and component, as structured annotations

5Pfam domainsDomain architecture mapped to Pfam families and clans

14+ReferencesStructured and connected to the statements they support

Which compounds in development act on High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A, and which indications are they being tested in?

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