Nuclear receptor-interacting protein 1
Details
- Name
- Nuclear receptor-interacting protein 1
- Kind
- protein
- Synonyms
- Nuclear factor RIP140
- Receptor-interacting protein 140
- Gene Name
- NRIP1
- UniProtKB Entry
- P48552Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0017211|Nuclear receptor-interacting protein 1 MTHGEELGSDVHQDSIVLTYLEGLLMHQAAGGSGTAVDKKSAGHNEEDQNFNISGSAFPT CQSNGPVLNTHTYQGSGMLHLKKARLLQSSEDWNAAKRKRLSDSIMNLNVKKEALLAGMV DSVPKGKQDSTLLASLLQSFSSRLQTVALSQQIRQSLKEQGYALSHDSLKVEKDLRCYGV ASSHLKTLLKKSKVKDQKPDTNLPDVTKNLIRDRFAESPHHVGQSGTKVMSEPLSCAARL QAVASMVEKRASPATSPKPSVACSQLALLLSSEAHLQQYSREHALKTQNANQAASERLAA MARLQENGQKDVGSYQLPKGMSSHLNGQARTSSSKLMASKSSATVFQNPMGIIPSSPKNA GYKNSLERNNIKQAANNSLLLHLLKSQTIPKPMNGHSHSERGSIFEESSTPTTIDEYSDN NPSFTDDSSGDESSYSNCVPIDLSCKHRTEKSESDQPVSLDNFTQSLLNTWDPKVPDVDI KEDQDTSKNSKLNSHQKVTLLQLLLGHKNEENVEKNTSPQGVHNDVSKFNTQNYARTSVI ESPSTNRTTPVSTPPLLTSSKAGSPINLSQHSLVIKWNSPPYVCSTQSEKLTNTASNHSM DLTKSKDPPGEKPAQNEGAQNSATFSASKLLQNLAQCGMQSSMSVEEQRPSKQLLTGNTD KPIGMIDRLNSPLLSNKTNAVEENKAFSSQPTGPEPGLSGSEIENLLERRTVLQLLLGNP NKGKSEKKEKTPLRDESTQEHSERALSEQILMVKIKSEPCDDLQIPNTNVHLSHDAKSAP FLGMAPAVQRSAPALPVSEDFKSEPVSPQDFSFSKNGLLSRLLRQNQDSYLADDSDRSHR NNEMALLESKNLCMVPKKRKLYTEPLENPFKKMKNNIVDAANNHSAPEVLYGSLLNQEEL KFSRNDLEFKYPAGHGSASESEHRSWARESKSFNVLKQLLLSENCVRDLSPHRSNSVADS KKKGHKNNVTNSKPEFSISSLNGLMYSSTQPSSCMDNRTFSYPGVVKTPVSPTFPEHLGC AGSRPESGLLNGCSMPSEKGPIKWVITDAEKNEYEKDSPRLTKTNPILYYMLQKGGNSVT SRETQDKDIWREASSAESVSQVTAKEELLPTAETKASFFNLRSPYNSHMGNNASRPHSAN GEVYGLLGSVLTIKKESE
- Number of residues
- 1158
- Molecular Weight
- 126940.855
- Theoretical pI
- 8.31
- GO Classification
- Functionstranscription coactivator activity / transcription corepressor activityProcessescellular response to estradiol stimulus / circadian regulation of gene expression / circadian rhythm / lipid storage / ovarian follicle ruptureComponentshistone deacetylase complex / nuclear speck / nucleolus / nucleoplasm / nucleus
- General Function
- Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors. Positive regulator of the circadian clock gene expression: stimulates transcription of BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC. Involved in the regulation of ovarian function (By similarity). Plays a role in renal development (PubMed:28381549)
- Specific Function
- histone deacetylase binding
- Pfam Domain Function
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Nucleus
- Gene sequence
>lcl|BSEQ0017212|Nuclear receptor-interacting protein 1 (NRIP1) ATGACTCATGGAGAAGAGCTTGGCTCTGATGTGCACCAGGATTCTATTGTTTTAACTTAC CTAGAAGGATTACTAATGCATCAGGCAGCAGGGGGATCAGGTACTGCCGTTGACAAAAAG TCTGCTGGGCATAATGAAGAGGATCAGAACTTTAACATTTCTGGCAGTGCATTTCCCACC TGTCAAAGTAATGGTCCAGTTCTCAATACACATACATATCAGGGGTCTGGCATGCTGCAC CTCAAAAAAGCCAGACTGTTGCAGTCTTCTGAGGACTGGAATGCAGCAAAGCGGAAGAGG CTGTCTGATTCTATCATGAATTTAAACGTAAAGAAGGAAGCTTTGCTAGCTGGCATGGTT GACAGTGTGCCTAAAGGCAAACAGGATAGCACATTACTGGCCTCTTTGCTTCAGTCATTC AGCTCTAGGCTGCAGACTGTTGCTCTGTCACAACAAATCAGGCAGAGCCTCAAGGAGCAA GGATATGCCCTCAGTCATGATTCTTTAAAAGTGGAGAAGGATTTAAGGTGCTATGGTGTT GCATCAAGTCACTTAAAAACTTTGTTGAAGAAAAGTAAAGTTAAAGATCAAAAGCCTGAT ACGAATCTTCCTGATGTGACTAAAAACCTCATCAGAGATAGGTTTGCAGAGTCTCCTCAT CATGTTGGACAAAGTGGAACAAAGGTCATGAGTGAACCGTTGTCATGTGCTGCAAGATTA CAGGCTGTTGCAAGCATGGTGGAAAAAAGGGCTAGTCCTGCCACCTCACCTAAACCTAGT GTTGCTTGTAGCCAGTTAGCATTACTTCTGTCAAGCGAAGCCCATTTGCAGCAGTATTCT CGAGAACACGCTTTAAAAACGCAAAATGCAAATCAAGCAGCAAGTGAAAGACTTGCTGCT ATGGCCAGATTGCAAGAAAATGGCCAGAAGGATGTTGGCAGTTACCAGCTCCCAAAAGGA ATGTCAAGCCATCTTAATGGTCAGGCAAGAACATCATCAAGCAAACTGATGGCTAGCAAA AGTAGTGCTACAGTGTTTCAAAATCCAATGGGTATCATTCCTTCTTCCCCTAAAAATGCA GGTTATAAGAACTCACTGGAAAGAAACAATATAAAACAAGCTGCTAACAATAGTTTGCTT TTACATCTTCTTAAAAGCCAGACTATACCTAAGCCAATGAATGGACACAGTCACAGTGAG AGAGGAAGCATTTTTGAGGAAAGTAGTACACCTACAACTATTGATGAATATTCAGATAAC AATCCTAGTTTTACAGATGACAGCAGTGGTGATGAAAGTTCTTATTCCAACTGTGTTCCC ATAGACTTGTCTTGCAAACACCGAACTGAAAAATCAGAATCTGACCAACCTGTTTCCCTG GATAACTTCACTCAATCCTTGCTAAACACTTGGGATCCAAAAGTCCCAGATGTAGATATC AAAGAAGATCAAGATACCTCAAAGAATTCTAAGCTAAACTCACACCAGAAAGTAACACTT CTTCAATTGCTACTTGGCCATAAGAATGAAGAAAATGTAGAAAAAAACACCAGCCCTCAG GGAGTACACAATGATGTGAGCAAGTTCAATACACAAAATTATGCAAGGACTTCTGTGATA GAAAGCCCCAGTACAAATCGGACTACTCCAGTGAGCACTCCACCTTTACTTACATCAAGC AAAGCAGGGTCTCCCATCAATCTCTCTCAACACTCTCTGGTCATCAAATGGAATTCCCCA CCATATGTCTGCAGTACTCAGTCTGAAAAGCTAACAAATACTGCATCTAACCACTCAATG GACCTTACAAAAAGCAAAGACCCACCAGGAGAGAAACCAGCCCAAAATGAAGGTGCACAG AACTCTGCAACGTTTAGTGCCAGTAAGCTGTTACAAAATTTAGCACAATGTGGAATGCAG TCATCCATGTCAGTGGAAGAGCAGAGACCCAGCAAACAGCTGTTAACTGGAAACACAGAT AAACCGATAGGTATGATTGATAGATTAAATAGCCCTTTGCTCTCAAATAAAACAAATGCA GTTGAAGAAAATAAAGCATTTAGTAGTCAACCAACAGGTCCTGAACCAGGGCTTTCTGGT TCTGAAATAGAAAATCTGCTTGAAAGACGTACTGTCCTCCAGTTGCTCCTGGGGAACCCC AACAAAGGGAAGAGTGAAAAAAAAGAGAAAACTCCCTTAAGAGATGAAAGTACTCAGGAA CACTCAGAGAGAGCTTTAAGTGAACAAATACTGATGGTGAAAATAAAATCTGAGCCTTGT GATGACTTACAAATTCCTAACACAAATGTGCACTTGAGCCATGATGCTAAGAGTGCCCCA TTCTTGGGTATGGCTCCTGCTGTGCAGAGAAGCGCACCTGCCTTACCAGTGTCCGAAGAC TTTAAATCGGAGCCTGTTTCACCTCAGGATTTTTCTTTCTCCAAGAATGGTCTGCTAAGT CGATTGCTAAGACAAAATCAAGATAGTTACCTGGCAGATGATTCAGACAGGAGTCACAGA AATAATGAAATGGCACTTCTAGAATCAAAGAATCTTTGCATGGTCCCTAAGAAAAGGAAG CTTTATACTGAGCCATTAGAAAATCCATTTAAAAAGATGAAAAACAACATTGTTGATGCT GCAAACAATCACAGTGCCCCAGAAGTACTGTATGGGTCCTTGCTTAACCAGGAAGAGCTG AAATTTAGCAGAAATGATCTTGAATTTAAATATCCTGCTGGTCATGGCTCAGCCAGCGAA AGTGAACACAGGAGTTGGGCCAGAGAGAGCAAAAGCTTTAATGTTCTGAAACAGCTGCTT CTCTCAGAAAACTGTGTGCGAGATTTGTCCCCGCACAGAAGTAACTCTGTGGCTGACAGT AAAAAGAAAGGACACAAAAATAATGTGACCAACAGCAAACCTGAATTTAGCATTTCTTCT TTAAATGGACTGATGTACAGTTCCACTCAGCCCAGCAGTTGCATGGATAACAGGACATTT TCATACCCAGGTGTAGTAAAAACTCCTGTGAGTCCTACTTTCCCTGAGCACTTGGGCTGT GCAGGGTCTAGACCAGAATCTGGGCTTTTGAATGGGTGTTCCATGCCCAGTGAGAAAGGA CCCATTAAGTGGGTTATCACTGATGCGGAGAAGAATGAGTATGAAAAAGACTCTCCAAGA TTGACCAAAACCAACCCAATACTATATTACATGCTTCAAAAAGGAGGCAATTCTGTTACC AGTCGAGAAACACAAGACAAGGACATTTGGAGGGAGGCTTCATCTGCTGAAAGTGTCTCA CAGGTCACAGCCAAAGAAGAGTTACTTCCTACTGCAGAAACGAAAGCTTCTTTCTTTAAT TTAAGAAGCCCTTACAATAGCCATATGGGAAATAATGCTTCTCGCCCACACAGCGCAAAT GGAGAAGTTTATGGACTTCTGGGAAGCGTGCTAACGATAAAGAAAGAATCAGAATAA
- Chromosome Location
- 21
- Locus
- 21q11.2-q21.1
- External Identifiers
Resource Link UniProtKB ID P48552 UniProtKB Entry Name NRIP1_HUMAN GenBank Protein ID 940539 GenBank Gene ID X84373 GeneCard ID NRIP1 HGNC ID HGNC:8001 PDB ID(s) 2GPO, 2GPP, 4S14, 4S15, 5NTI, 5NTN, 5NTW, 5NU1, 6FZU, 6G05, 6G07 KEGG ID hsa:8204 NCBI Gene ID 8204 - General References
- Cavailles V, Dauvois S, L'Horset F, Lopez G, Hoare S, Kushner PJ, Parker MG: Nuclear factor RIP140 modulates transcriptional activation by the estrogen receptor. EMBO J. 1995 Aug 1;14(15):3741-51. [Article]
- Hattori M, Fujiyama A, Taylor TD, Watanabe H, Yada T, Park HS, Toyoda A, Ishii K, Totoki Y, Choi DK, Groner Y, Soeda E, Ohki M, Takagi T, Sakaki Y, Taudien S, Blechschmidt K, Polley A, Menzel U, Delabar J, Kumpf K, Lehmann R, Patterson D, Reichwald K, Rump A, Schillhabel M, Schudy A, Zimmermann W, Rosenthal A, Kudoh J, Schibuya K, Kawasaki K, Asakawa S, Shintani A, Sasaki T, Nagamine K, Mitsuyama S, Antonarakis SE, Minoshima S, Shimizu N, Nordsiek G, Hornischer K, Brant P, Scharfe M, Schon O, Desario A, Reichelt J, Kauer G, Blocker H, Ramser J, Beck A, Klages S, Hennig S, Riesselmann L, Dagand E, Haaf T, Wehrmeyer S, Borzym K, Gardiner K, Nizetic D, Francis F, Lehrach H, Reinhardt R, Yaspo ML: The DNA sequence of human chromosome 21. Nature. 2000 May 18;405(6784):311-9. [Article]
- Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
- Yan ZH, Karam WG, Staudinger JL, Medvedev A, Ghanayem BI, Jetten AM: Regulation of peroxisome proliferator-activated receptor alpha-induced transactivation by the nuclear orphan receptor TAK1/TR4. J Biol Chem. 1998 May 1;273(18):10948-57. [Article]
- Subramaniam N, Treuter E, Okret S: Receptor interacting protein RIP140 inhibits both positive and negative gene regulation by glucocorticoids. J Biol Chem. 1999 Jun 18;274(25):18121-7. [Article]
- Vo N, Fjeld C, Goodman RH: Acetylation of nuclear hormone receptor-interacting protein RIP140 regulates binding of the transcriptional corepressor CtBP. Mol Cell Biol. 2001 Sep;21(18):6181-8. [Article]
- Zilliacus J, Holter E, Wakui H, Tazawa H, Treuter E, Gustafsson JA: Regulation of glucocorticoid receptor activity by 14--3-3-dependent intracellular relocalization of the corepressor RIP140. Mol Endocrinol. 2001 Apr;15(4):501-11. [Article]
- Zennaro MC, Souque A, Viengchareun S, Poisson E, Lombes M: A new human MR splice variant is a ligand-independent transactivator modulating corticosteroid action. Mol Endocrinol. 2001 Sep;15(9):1586-98. [Article]
- Tazawa H, Osman W, Shoji Y, Treuter E, Gustafsson JA, Zilliacus J: Regulation of subnuclear localization is associated with a mechanism for nuclear receptor corepression by RIP140. Mol Cell Biol. 2003 Jun;23(12):4187-98. [Article]
- Teyssier C, Belguise K, Galtier F, Cavailles V, Chalbos D: Receptor-interacting protein 140 binds c-Jun and inhibits estradiol-induced activator protein-1 activity by reversing glucocorticoid receptor-interacting protein 1 effect. Mol Endocrinol. 2003 Feb;17(2):287-99. [Article]
- Christian M, Tullet JM, Parker MG: Characterization of four autonomous repression domains in the corepressor receptor interacting protein 140. J Biol Chem. 2004 Apr 9;279(15):15645-51. Epub 2004 Jan 21. [Article]
- Castet A, Boulahtouf A, Versini G, Bonnet S, Augereau P, Vignon F, Khochbin S, Jalaguier S, Cavailles V: Multiple domains of the Receptor-Interacting Protein 140 contribute to transcription inhibition. Nucleic Acids Res. 2004 Apr 1;32(6):1957-66. Print 2004. [Article]
- Huq MD, Gupta P, Tsai NP, Wei LN: Modulation of testicular receptor 4 activity by mitogen-activated protein kinase-mediated phosphorylation. Mol Cell Proteomics. 2006 Nov;5(11):2072-82. Epub 2006 Aug 3. [Article]
- Lopez-Garcia J, Periyasamy M, Thomas RS, Christian M, Leao M, Jat P, Kindle KB, Heery DM, Parker MG, Buluwela L, Kamalati T, Ali S: ZNF366 is an estrogen receptor corepressor that acts through CtBP and histone deacetylases. Nucleic Acids Res. 2006;34(21):6126-36. Epub 2006 Nov 3. [Article]
- Poliandri AH, Gamsby JJ, Christian M, Spinella MJ, Loros JJ, Dunlap JC, Parker MG: Modulation of clock gene expression by the transcriptional coregulator receptor interacting protein 140 (RIP140). J Biol Rhythms. 2011 Jun;26(3):187-99. doi: 10.1177/0748730411401579. [Article]
- Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62. doi: 10.1016/j.jprot.2013.11.014. Epub 2013 Nov 22. [Article]
- Hendriks IA, D'Souza RC, Yang B, Verlaan-de Vries M, Mann M, Vertegaal AC: Uncovering global SUMOylation signaling networks in a site-specific manner. Nat Struct Mol Biol. 2014 Oct;21(10):927-36. doi: 10.1038/nsmb.2890. Epub 2014 Sep 14. [Article]
- Wang L, Zuercher WJ, Consler TG, Lambert MH, Miller AB, Orband-Miller LA, McKee DD, Willson TM, Nolte RT: X-ray crystal structures of the estrogen-related receptor-gamma ligand binding domain in three functional states reveal the molecular basis of small molecule regulation. J Biol Chem. 2006 Dec 8;281(49):37773-81. Epub 2006 Sep 21. [Article]
- Caballero V, Ruiz R, Sainz JA, Cruz M, Lopez-Nevot MA, Galan JJ, Real LM, de Castro F, Lopez-Villaverde V, Ruiz A: Preliminary molecular genetic analysis of the Receptor Interacting Protein 140 (RIP140) in women affected by endometriosis. J Exp Clin Assist Reprod. 2005 Aug 30;2:11. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details 4-HYDROXY-N'-(4-ISOPROPYLBENZYL)BENZOHYDRAZIDE experimental unknown target Details