Serine/threonine-protein kinase PLK1

BE0003745ProteinHumansPLK1

Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome... It is acted on by 15 drugs in DrugBank.

Gene name
PLK1
UniProtKB entry
P53350Swiss-Prot
Cellular location
Nucleus
Residues / weight
603 residues · 68,254 Da
Also known as
2.7.11.21 · PLK · PLK-1 · Polo-like kinase 1 · Serine/threonine-protein kinase 13

Resolves to

Protein
UniProtP53350UniProt namePLK1_HUMAN
Gene
HGNCHGNC:9077NCBI Gene5347GenBank393017GeneCardsPLK1
Pharmacology
IUPHAR/GtoPdb2168KEGGhsa:5347
Structure
PDB1Q4KPDB1Q4OPDB1UMW
Drugs

What you can answer from here — as of September 07, 2019

15DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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34GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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106+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Serine/threonine-protein kinase PLK1, how selective are they, and which programs against it are still in active trials?

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