Chymotrypsin-like elastase family member 2A
Details
- Name
- Chymotrypsin-like elastase family member 2A
- Kind
- protein
- Synonyms
- 3.4.21.71
- ELA2A
- Elastase-2A
- Gene Name
- CELA2A
- UniProtKB Entry
- P08217Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0012615|Chymotrypsin-like elastase family member 2A MIRTLLLSTLVAGALSCGDPTYPPYVTRVVGGEEARPNSWPWQVSLQYSSNGKWYHTCGG SLIANSWVLTAAHCISSSRTYRVGLGRHNLYVAESGSLAVSVSKIVVHKDWNSNQISKGN DIALLKLANPVSLTDKIQLACLPPAGTILPNNYPCYVTGWGRLQTNGAVPDVLQQGRLLV VDYATCSSSAWWGSSVKTSMICAGGDGVISSCNGDSGGPLNCQASDGRWQVHGIVSFGSR LGCNYYHKPSVFTRVSNYIDWINSVIANN
- Number of residues
- 269
- Molecular Weight
- 28887.5
- Theoretical pI
- 8.54
- GO Classification
- Functionsserine hydrolase activity / serine-type endopeptidase activityProcessesproteolysisComponentsextracellular space / keratohyalin granule
- General Function
- Elastase that enhances insulin signaling and might have a physiologic role in cellular glucose metabolism. Circulates in plasma and reduces platelet hyperactivation, triggers both insulin secretion and degradation, and increases insulin sensitivity
- Specific Function
- endopeptidase activity
- Pfam Domain Function
- Trypsin (PF00089)
- Signal Regions
- 1-16
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0012616|Chymotrypsin-like elastase family member 2A (CELA2A) ATGATAAGGACGCTGCTGCTGTCCACTTTGGTGGCTGGAGCCCTCAGTTGTGGGGACCCC ACTTACCCACCTTATGTGACTAGGGTGGTTGGCGGTGAAGAAGCGAGGCCCAACAGCTGG CCCTGGCAGGTCTCCCTGCAGTACAGCTCCAATGGCAAGTGGTACCACACCTGCGGAGGG TCCCTGATAGCCAACAGCTGGGTCCTGACGGCTGCCCACTGCATCAGCTCCTCCAGGACC TACCGCGTGGGGCTGGGCCGGCACAACCTCTACGTTGCGGAGTCCGGCTCGCTGGCAGTC AGTGTCTCTAAGATTGTGGTGCACAAGGACTGGAACTCCAACCAAATCTCCAAAGGGAAC GACATTGCCCTGCTCAAACTGGCTAACCCCGTCTCCCTCACCGACAAGATCCAGCTGGCC TGCCTCCCTCCTGCCGGCACCATTCTACCCAACAACTACCCCTGCTACGTCACGGGCTGG GGAAGGCTGCAGACCAACGGGGCTGTTCCTGATGTCCTGCAGCAGGGCCGGTTGCTGGTT GTGGACTATGCCACCTGCTCCAGCTCTGCCTGGTGGGGCAGCAGCGTGAAAACCAGTATG ATCTGTGCTGGGGGTGATGGCGTGATCTCCAGCTGCAACGGAGACTCTGGCGGGCCACTG AACTGTCAGGCGTCTGACGGCCGGTGGCAGGTGCACGGCATCGTCAGCTTCGGGTCTCGC CTCGGCTGCAACTACTACCACAAGCCCTCCGTCTTCACGCGGGTCTCCAATTACATCGAC TGGATCAATTCGGTGATTGCAAATAACTAA
- Chromosome Location
- 1
- Locus
- 1p36.21
- External Identifiers
Resource Link UniProtKB ID P08217 UniProtKB Entry Name CEL2A_HUMAN GenBank Protein ID 182023 GenBank Gene ID M16631 GeneCard ID CELA2A HGNC ID HGNC:24609 KEGG ID hsa:63036 NCBI Gene ID 63036 - General References
- Fletcher TS, Shen WF, Largman C: Primary structure of human pancreatic elastase 2 determined by sequence analysis of the cloned mRNA. Biochemistry. 1987 Nov 17;26(23):7256-61. [Article]
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- Shirasu Y, Yoshida H, Matsuki S, Takemura K, Ikeda N, Shimada Y, Ozawa T, Mikayama T, Iijima H, Ishida A, et al.: Molecular cloning and expression in Escherichia coli of a cDNA encoding human pancreatic elastase 2. J Biochem. 1987 Dec;102(6):1555-63. [Article]
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Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details 2-(2-HYDROXY-CYCLOPENTYL)-PENT-4-ENAL experimental unknown target Details