Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform

BE0003749ProteinHumansPPP2R5C

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment. It is acted on by 2 drugs in DrugBank.

Gene name
PPP2R5C
UniProtKB entry
Q13362Swiss-Prot
Cellular location
Nucleus
Residues / weight
524 residues · 61,060 Da
Also known as
KIAA0044 · PP2A B subunit isoform B'-gamma · PP2A B subunit isoform B56-gamma · PP2A B subunit isoform PR61-gamma · PP2A B subunit isoform R5-gamma

Resolves to

Protein
UniProtQ13362UniProt name2A5G_HUMAN
Gene
HGNCHGNC:9311NCBI Gene5527GenBank1203812GeneCardsPPP2R5C
Pharmacology
KEGGhsa:5527
Structure
PDB2IAEPDB2JAKPDB2NPP
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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21+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform, and which indications are they being tested in?

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