Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

BE0003750ProteinHumansPPP2R1A

The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit (PubMed:15525651, PubMed:16580887, PubMed:33243860, PubMed:33633399, PubMed:34004147, PubMed:8694763). It is acted on by 3 drugs in DrugBank.

Gene name
PPP2R1A
UniProtKB entry
P30153Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
589 residues · 65,308 Da
Also known as
Medium tumor antigen-associated 61 kDa protein · PP2A subunit A isoform PR65-alpha · PP2A subunit A isoform R1-alpha · PP2Aa

Resolves to

Protein
UniProtP30153UniProt name2AAA_HUMAN
Gene
HGNCHGNC:9302NCBI Gene5518GenBank178663GeneCardsPPP2R1A
Pharmacology
KEGGhsa:5518
Structure
PDB1B3UPDB2IE3PDB2IE4
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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17GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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24+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, and which indications are they being tested in?

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