Cytochrome P450
Details
- Name
- Cytochrome P450
- Kind
- protein
- Synonyms
- Not Available
- Gene Name
- staP
- UniProtKB Entry
- Q83WG3TrEMBL
- Organism
- Streptomyces sp. TP-A0274
- NCBI Taxonomy ID
- 171258
- Amino acid sequence
>lcl|BSEQ0012625|Cytochrome P450 MASATLPRFDLMGWDKKDIADPYPVYRRYREAAPVHRTASGPGKPDTYYVFTYDDVVRVL SNRRLGRNARVASGDTDTAPVPIPTEHRALRTVVENWLVFLDPPHHTELRSLLTTEFSPS IVTGLRPRIAELASALLDRLRAQRRPDLVEGFAAPLPILVISALLGIPEEDHTWLRANAV ALQEASTTRARDGRGYARAEAASQEFTRYFRREVDRRGGDDRDDLLTLLVRARDTGSPLS VDGIVGTCVHLLTAGHETTTNFLAKAVLTLRAHRDVLDELRTTPESTPAAVEELMRYDPP VQAVTRWAYEDIRLGDHDIPRGSRVVALLGSANRDPARFPDPDVLDVHRAAERQVGFGLG IHYCLGATLARAEAEIGLRALLDGIPALGRGAHEVEYADDMVFHGPTRLLLDLPDAA
- Number of residues
- 417
- Molecular Weight
- 46125.6
- Theoretical pI
- 6.33
- GO Classification
- Functionsheme binding / iron ion binding / monooxygenase activity / oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
- General Function
- Not Available
- Specific Function
- cholest-4-en-3-one 26-monooxygenase activity
- Pfam Domain Function
- p450 (PF00067)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0007215|2832 bp ATGAGGGAGAAAATGCACAGCTGTTCACGGTCGGCAATGGCAAAGTGCGAGAATCCGGTT CTCAACGCAGTTCACACACAGCCCATTTCCCGGGGAGCAGTGCACGGCAGGGAAGACCAA CTGGCCCAGACGATCACGCAGCTGCGCGCCGTGGCGAGCAGCGGGCGGAGCACGGTGCTG GTGCTGGGGGCGGTTCCCGGCGCCGGCAAGACCCGGCTCCTCAGGGAGGCGGCGTCGCTC GCCGAGAGCGACGGCTTCATGGTGCTGAGCGCCGCCCCGGCCGGGCCCGACACCACCCCC GAGGCCGTCATCGAGGCGGCGCGGACACGGCTCCCCGGCGCCGGGAGCACCCGCACCACC GTCGTCCTCGACGATCTGCATCTGGCGGGACTCCCCGCACTGACGACGCTGAACGACCTC GTCGTGGCCCTCAGGGGACGTCCGATCCTCTGGCTGCTCGCCTTCACCACGGAACGCGAC GCCCCACCCCCGGAACACCTGCGGGCCTCTCTCGGCGGACTCCGCGCCAGCCTCCCGGTG GAGCACATGCGGGAGCTGGGACCGATCGAGGGCGACGCGCTGGCACAGTTGGTCGCCGAC CACACCGGAGCCACCCCCGACCCGGCTCTCCTCGCCCTCGCGGAGAGCGTCAACGCCACG CCGCGCTCGGTGATCGAGTTGATTCGCGGCCTGGCGGAGGACGACGACCTGTGCCTGATC GACGGCACCACCCGATTACAGCCCGGCCCACCCGGCGACCCCTCGGCCGGGTGGGGCGTC CCGGTGCCCACCCCCGTACCGAAACGGTTCTCCGCGACCGTCCAGCAAGACCTCAGGACA CTGTCGGACCCCACCCTGAAGGCGCTCAGACTGGCCGCCGTCCTCGGATCACCGTTCGCA CCGGAAGACCTGTCGGCCCTGCTCGACGAAGCACCCGTCGGTCTGCTCGCCGCCGTGGAC GAGGCCGTCGACCGGGGCCTGCTCGTCTGCGGCGAACGCGACCTCGCCTTCCGCACCGAG CCGATCTGGCGGGTCCTGCTCGACTCCGTACCGCCCCCGGTGCTCGCCCTGCTGCGCCGG CAGGCCGCGAAGATCGTGCTGCCGCGCCCCGACGGCGTCGAGCGCGCCGCCCTCCAACTG GTCCACGTCGCCCAACCCGGCAACACGGACGAACTGCGCATCATCGCCGAGGGCTCCCGC AGACTCCTGCTCGCCGACCCGTCCGCAGCCGCCTCGCTCGCCACCCGCTCCATGGAGTTC CTGGACCCCGGCACCGCCGAGCGGGTGCGACTGGCACGGACCGCCGTCGAAGCGCTCACC AGAGCCGGCCGACTGGACCACGCGATCGCCCTGGCCAAGGACACCGTCGACGAGACAGCC CGCCTCGCCGCCCCACTGCCGCCGGAGCTCGTCGAGGACGTCGCCGCGTTGCGGGCCTCG ATGTCGACCGCCCTGCTGCTCCTCGGCGACGCCCGCCTCGCCCGCCGAGCGGCAGGCGAC GCGCTCGCGGTACAGCACGGCGGGCCCCAGCACCGCGAGGCGGTCGTCGCCCACCTCGCC GCCTCCTACCTCACCGGCGACGCCAGCGCCGCCCAGCGCGCACGCCAGATCCTCGGCGCA CCCGACCGCCACACCGGCGCCGTGCAGGTGGGCGCGATGACCTTCCACGCCTTCGGCCAG TGGCGCGCCGGCGACGTCGGCGAGGCCGTGGCCACCCTGCGCAGGGCGGTCGCCCTCGAC CGCGCCGACGACGAGGCGCCGATCCTCGACCCCCGCTGGTTCCTCACCTTCACCCTCGCC AGGACCGACGAGTACGAGCAGGCGGCGGCCGTCATCCGGAGCTCCGCCGCCATCGCCTCG AAACACGGCACGCTGACCACCGCGGTCCCCGCCGTGCTCCGCGCCCAACTGAACCTCGCA CAGGGCCGGTTGGACGAGGCGGAGGACGACGCCAAGCTCGGGGTCGGCACCGACGGCCCC TTTGTGCCGATGCTCGCCCCGCAGGCATGGCTGGTTCTAGCCTCCGTGGCCCTGCGCCGA GGAGCGCTCGCCCAGGCCGAGGAACACATCAAGACCCTGGAGAAGGACTTCCCCCAGCAC GCCTCCAGCCCCTGGTGGGGCGCGCGGCTGCTGCTCAACGCGCAGTTGGCCGAGGCACAG GCCGACCAGCACGCCGCGACGGAGGTGCTGGCCGAGATCGGGGCGCAGAACGGTGCGCTC CGCGAGGTCGTCCTGGAGGATCCGGCCGCGGCGGCCTGGTGGGTACGGTGCGCTCTCGCG GCCGAGCGACCCGACCTCGTCTCGACGGTGATCGAGGCGACGGAGCACCTCCGTGGACGC AACCAGTGCGTGCCCTCGGTGGTGGCCATGGCCATGCACGCCCGGGCGCTCGCCGAAGGG GACGCCGAGGCACTCGACCGGGCCGGGCGGCTACACCGCAATCCCTGGGCGCAGGCGACC GCGGCCGAGGACCACGCGGGGCTGCTCCTCGACCGTGGGGAGCACGAGGCCGCCATCGGT GAGTTCGACCGGGCGATGAGCGCCTTCGGCGCGCTCGGCGGGGAGCGGGACGCCGCCCGG GTGCGGGCGCGGCTGCGTGCGCTGGGGGTACGGCGGCGGCACTGGACGCATGCGAAACGT CCGGTGTCCGGGTGGGAGAGCCTGACCAAGACCGAGCGGAAGGTGGCCGAGCTGGTGGCC GGGGGGCTCACCAATCAGCAGGCCGCCCGGCATCTGTTCATCTCACCGCACACGGTCGGG TTCCATCTGCGCCAGATCTACCGGAAGTTGGGCATCCGGTCGCGCACCGCGCTGATTCGG CTGAGGGCGTGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q83WG3 UniProtKB Entry Name Q83WG3_9ACTN GenBank Protein ID 27753571 GenBank Gene ID AB088119 PDB ID(s) 2Z3T, 2Z3U, 3A1L - General References
- Makino M, Sugimoto H, Shiro Y, Asamizu S, Onaka H, Nagano S: Crystal structures and catalytic mechanism of cytochrome P450 StaP that produces the indolocarbazole skeleton. Proc Natl Acad Sci U S A. 2007 Jul 10;104(28):11591-6. Epub 2007 Jul 2. [Article]
- Wang Y, Chen H, Makino M, Shiro Y, Nagano S, Asamizu S, Onaka H, Shaik S: Theoretical and experimental studies of the conversion of chromopyrrolic acid to an antitumor derivative by cytochrome P450 StaP: the catalytic role of water molecules. J Am Chem Soc. 2009 May 20;131(19):6748-62. doi: 10.1021/ja9003365. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details 3,4-bis(7-chloro-1H-indol-3-yl)-1H-pyrrole-2,5-dicarboxylic acid experimental unknown target Details 3,4-DI-1H-INDOL-3-YL-1H-PYRROLE-2,5-DICARBOXYLIC ACID experimental unknown target Details