UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
Details
- Name
- UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
- Kind
- protein
- Synonyms
- 6.3.2.10
- D-alanyl-D-alanine-adding enzyme
- Gene Name
- murF
- UniProtKB Entry
- Q8DNV6TrEMBL
- Organism
- Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
- NCBI Taxonomy ID
- 171101
- Amino acid sequence
>lcl|BSEQ0022438|UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MKLTIHEIAQVVGAKNDISIFEDTQLEKAEFDSRLIGTGDLFVPLKGARDGHDFIETAFE NGAAVTLSEKEVSNHPYILVDDVLTAFQSLASYYLEKTTVDVFAVTGSNGKTTTKDMLAH LLSTRYKTYKTQGNYNNEIGLPYTVLHMPEGTEKLVLEMGQDHLGDIHLLSELARPKTAI VTLVGEAHLAFFKDRSEIAKGKMQIADGMASGSLLLAPADPIVEDYLPIDKKVVRFGQGA ELEITDLVERKDSLTFKANFLEQALDLPVTGKYNATNAMIASYVALQEGVSEEQIRLAFQ HLELTRNRTEWKKAANGADILSDVYNANPTAMKLILETFSAIPANEGGKKIAVLADMKEL GDQSVQLHNQMILSLSPDVLDIVIFYGEDIAQLAQLASQMFPIGHVYYFKKTEDQDQFED LVKQVKESLGAHDQILLKGSNSMNLAKLVESLENEDK
- Number of residues
- 457
- Molecular Weight
- 50502.04
- Theoretical pI
- 4.64
- GO Classification
- FunctionsATP binding / UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity / UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activityProcessescell cycle / cell division / cell wall organization / peptidoglycan biosynthetic process / regulation of cell shapeComponentscytoplasm
- General Function
- Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.
- Specific Function
- ATP binding
- Pfam Domain Function
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0022439|UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase (murF) ATGAAATTAACAATCCATGAAATTGCCCAAGTTGTTGGAGCCAAAAATGATATCAGTATC TTTGAGGACACTCAGTTAGAAAAAGCTGAGTTTGATAGTCGTTTGATTGGAACTGGAGAT TTATTTGTGCCACTTAAAGGTGCGCGTGATGGCCATGACTTTATTGAAACAGCCTTTGAA AATGGTGCAGCAGTAACCTTGTCTGAGAAAGAGGTCTCAAATCATCCTTACATTTTAGTA GATGATGTTTTGACAGCCTTTCAATCCCTAGCATCCTACTATCTTGAAAAAACGACTGTT GATGTCTTTGCTGTTACAGGTTCAAATGGCAAGACAACGACTAAGGATATGTTGGCGCAT TTACTGTCAACAAGATACAAGACCTACAAAACACAAGGCAATTACAATAATGAGATTGGC CTTCCTTACACAGTTCTTCATATGCCTGAAGGAACAGAAAAGTTGGTTTTGGAGATGGGA CAGGATCACTTGGGAGATATTCATCTCTTGTCTGAATTGGCTCGTCCAAAAACAGCCATC GTGACCTTGGTTGGAGAAGCTCATTTGGCCTTTTTCAAAGATCGTTCTGAGATTGCTAAA GGAAAAATGCAAATTGCAGACGGAATGGCTTCAGGTTCCTTGCTTTTAGCGCCGGCTGAC CCTATCGTAGAGGACTATTTGCCAATTGATAAAAAGGTGGTTCGTTTTGGTCAAGGAGCA GAGCTGGAAATTACTGACTTGGTTGAGCGTAAGGACAGTCTGACCTTTAAGGCTAATTTC TTGGAACAAGCCCTTGATTTGCCAGTAACTGGCAAGTACAATGCGACAAATGCTATGATT GCATCCTATGTTGCCTTGCAAGAAGGAGTTTCAGAGGAGCAAATTCGTTTGGCATTCCAA CATCTTGAATTGACGCGTAACCGTACCGAGTGGAAGAAAGCAGCCAATGGAGCAGATATC CTGTCAGATGTTTACAATGCCAATCCAACTGCTATGAAACTGATTTTAGAGACTTTCTCT GCCATTCCAGCCAATGAAGGTGGCAAGAAAATTGCAGTGTTGGCGGATATGAAGGAGCTT GGTGACCAGTCTGTTCAACTTCATAATCAGATGATTTTGAGCCTCTCCCCAGATGTGCTT GATATCGTTATTTTCTATGGAGAAGATATTGCTCAGTTGGCTCAATTGGCCAGTCAAATG TTCCCAATCGGCCACGTTTACTACTTCAAGAAAACAGAAGACCAGGATCAATTTGAAGAC CTAGTCAAGCAGGTCAAGGAAAGCCTTGGAGCCCATGACCAAATCCTGCTCAAAGGCTCT AACTCTATGAATCTAGCCAAGTTGGTAGAAAGTTTAGAAAATGAAGACAAGTGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q8DNV6 UniProtKB Entry Name Q8DNV6_STRR6 GenBank Protein ID 15457529 GenBank Gene ID AE007317 PDB ID(s) 2AM1, 2AM2, 3ZM5, 3ZM6 KEGG ID spr:spr1514 NCBI Gene ID 933049 - General References
- Hoskins J, Alborn WE Jr, Arnold J, Blaszczak LC, Burgett S, DeHoff BS, Estrem ST, Fritz L, Fu DJ, Fuller W, Geringer C, Gilmour R, Glass JS, Khoja H, Kraft AR, Lagace RE, LeBlanc DJ, Lee LN, Lefkowitz EJ, Lu J, Matsushima P, McAhren SM, McHenney M, McLeaster K, Mundy CW, Nicas TI, Norris FH, O'Gara M, Peery RB, Robertson GT, Rockey P, Sun PM, Winkler ME, Yang Y, Young-Bellido M, Zhao G, Zook CA, Baltz RH, Jaskunas SR, Rosteck PR Jr, Skatrud PL, Glass JI: Genome of the bacterium Streptococcus pneumoniae strain R6. J Bacteriol. 2001 Oct;183(19):5709-17. [Article]
- Longenecker KL, Stamper GF, Hajduk PJ, Fry EH, Jakob CG, Harlan JE, Edalji R, Bartley DM, Walter KA, Solomon LR, Holzman TF, Gu YG, Lerner CG, Beutel BA, Stoll VS: Structure of MurF from Streptococcus pneumoniae co-crystallized with a small molecule inhibitor exhibits interdomain closure. Protein Sci. 2005 Dec;14(12):3039-47. [Article]
- Hrast M, Turk S, Sosic I, Knez D, Randall CP, Barreteau H, Contreras-Martel C, Dessen A, O'Neill AJ, Mengin-Lecreulx D, Blanot D, Gobec S: Structure-activity relationships of new cyanothiophene inhibitors of the essential peptidoglycan biosynthesis enzyme MurF. Eur J Med Chem. 2013 Aug;66:32-45. doi: 10.1016/j.ejmech.2013.05.013. Epub 2013 May 21. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details 2-CHLORO-N-(3-CYANO-5,6-DIHYDRO-4H-CYCLOPENTA[B]THIOPHEN-2-YL)-5-DIETHYLSULFAMOYL-BENZAMIDE experimental unknown target Details