S-phase kinase-associated protein 1

BE0003767ProteinHumansSKP1

Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. It is acted on by 5 drugs in DrugBank.

Gene name
SKP1
UniProtKB entry
P63208Swiss-Prot
Residues / weight
163 residues · 18,658 Da
Also known as
Cyclin-A/CDK2-associated protein p19 · EMC19 · OCP-2 · OCP-II · OCP2

Resolves to

Protein
UniProtP63208UniProt nameSKP1_HUMAN
Gene
HGNCHGNC:10899NCBI Gene6500GenBank995824GeneCardsSKP1
Pharmacology
KEGGhsa:6500
Structure
PDB1FQVPDB1FS1PDB1FS2
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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42GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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30+ReferencesStructured and connected to the statements they support
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Which compounds in development act on S-phase kinase-associated protein 1, and which indications are they being tested in?

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