Uracil-DNA glycosylase

BE0003770ProteinHumansUNG

Uracil-DNA glycosylase that hydrolyzes the N-glycosidic bond between uracil and deoxyribose in single- and double-stranded DNA (ssDNA and dsDNA) to release a free uracil residue and form an abasic (apurinic/apyrimidinic; AP) site. It is acted on by 3 drugs in DrugBank.

Gene name
UNG
UniProtKB entry
P13051Swiss-Prot
Cellular location
Mitochondrion
Residues / weight
313 residues · 34,645 Da
Also known as
3.2.2.27 · DGU · UDG · UNG1 · UNG15

Resolves to

Protein
UniProtP13051UniProt nameUNG_HUMAN
Gene
HGNCHGNC:12572NCBI Gene7374GenBank37599GeneCardsUNG
Pharmacology
KEGGhsa:7374
Structure
PDB1AKZPDB1DPUPDB1EMH
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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29+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Uracil-DNA glycosylase, and which indications are they being tested in?

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