DNA ligase

BE0003773ProteinHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)ligA

DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is acted on by 1 drug in DrugBank.

Gene name
ligA
UniProtKB entry
P43813Swiss-Prot
Cellular location
Cytoplasmic
Residues / weight
670 residues · 74,042 Da
Also known as
6.5.1.2 · lig · ligN · Polydeoxyribonucleotide synthase [NAD(+)]

Resolves to

Protein
UniProtP43813UniProt nameDNLJ_HAEIN
Gene
NCBI Gene950070GenBank3212176
Pharmacology
KEGGhin:HI1100
Structure
PDB3BACPDB3PN1PDB3UQ8
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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2+ReferencesStructured and connected to the statements they support
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Which compounds in development act on DNA ligase, and which indications are they being tested in?

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