Adenosylhomocysteinase
Details
- Name
- Adenosylhomocysteinase
- Kind
- protein
- Synonyms
- 3.3.1.1
- AdoHcyase
- S-adenosyl-L-homocysteine hydrolase
- sahH
- Gene Name
- ahcY
- UniProtKB Entry
- P9WGV3Swiss-Prot
- Organism
- Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
- NCBI Taxonomy ID
- 83332
- Amino acid sequence
>lcl|BSEQ0051221|Adenosylhomocysteinase MTGNLVTKNSLTPDVRNGIDFKIADLSLADFGRKELRIAEHEMPGLMSLRREYAEVQPLK GARISGSLHMTVQTAVLIETLTALGAEVRWASCNIFSTQDHAAAAVVVGPHGTPDEPKGV PVFAWKGETLEEYWWAAEQMLTWPDPDKPANMILDDGGDATMLVLRGMQYEKAGVVPPAE EDDPAEWKVFLNLLRTRFETDKDKWTKIAESVKGVTEETTTGVLRLYQFAAAGDLAFPAI NVNDSVTKSKFDNKYGTRHSLIDGINRGTDALIGGKKVLICGYGDVGKGCAEAMKGQGAR VSVTEIDPINALQAMMEGFDVVTVEEAIGDADIVVTATGNKDIIMLEHIKAMKDHAILGN IGHFDNEIDMAGLERSGATRVNVKPQVDLWTFGDTGRSIIVLSEGRLLNLGNATGHPSFV MSNSFANQTIAQIELWTKNDEYDNEVYRLPKHLDEKVARIHVEALGGHLTKLTKEQAEYL GVDVEGPYKPDHYRY
- Number of residues
- 495
- Molecular Weight
- 54323.25
- Theoretical pI
- Not Available
- GO Classification
- Functionsadenosylhomocysteinase activity / NAD+ binding / zymogen bindingProcessesadenosine metabolic process / adhesion of symbiont to host cell / entry of bacterium into host cell / growth / methionine catabolic process / one-carbon metabolic process / S-adenosylhomocysteine catabolic process / S-adenosylmethionine cycleComponentscell wall / cytosol / extracellular region / plasma membrane
- General Function
- May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
- Specific Function
- adenosylhomocysteinase activity
- Pfam Domain Function
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0051222|Adenosylhomocysteinase (ahcY) ATGACCGGAAATTTGGTGACCAAAAATTCGCTGACCCCTGACGTTCGTAACGGCATCGAC TTTAAGATCGCCGACCTGTCACTAGCGGATTTCGGCCGCAAAGAACTCCGGATCGCCGAG CACGAGATGCCCGGCCTGATGTCGCTGCGGCGCGAGTATGCCGAGGTGCAACCCCTGAAG GGGGCCCGGATCTCGGGTTCGCTGCACATGACGGTGCAGACCGCGGTGTTGATCGAAACC CTCACCGCGCTGGGCGCCGAAGTCCGCTGGGCCTCGTGCAACATCTTCTCCACCCAGGAT CACGCCGCCGCCGCCGTCGTGGTCGGCCCGCACGGCACCCCCGACGAGCCCAAGGGTGTC CCGGTGTTCGCGTGGAAGGGCGAGACGCTCGAAGAGTACTGGTGGGCCGCCGAGCAGATG CTCACCTGGCCGGACCCCGACAAGCCGGCCAACATGATCCTCGATGACGGCGGTGACGCC ACCATGTTGGTGCTGCGCGGCATGCAGTATGAGAAGGCCGGCGTGGTGCCGCCCGCCGAG GAGGACGACCCCGCCGAGTGGAAGGTCTTCCTGAACCTGCTACGGACCCGCTTCGAGACC GACAAGGACAAGTGGACCAAGATAGCCGAGTCGGTCAAGGGCGTCACCGAGGAGACCACC ACCGGCGTGCTGCGGCTCTACCAATTCGCCGCGGCCGGGGATCTGGCCTTCCCGGCGATC AACGTCAACGACTCGGTGACCAAGTCCAAATTCGACAACAAGTACGGCACTCGGCACTCC CTGATCGACGGCATCAACCGCGGCACCGACGCGCTGATCGGCGGTAAGAAGGTCCTCATC TGCGGCTACGGCGACGTCGGTAAGGGCTGTGCGGAGGCGATGAAGGGCCAGGGAGCGCGG GTCTCCGTCACCGAGATCGACCCGATCAACGCGCTGCAGGCCATGATGGAGGGCTTCGAC GTGGTCACCGTCGAGGAGGCCATCGGGGACGCCGACATCGTCGTAACCGCGACCGGCAAC AAAGACATCATCATGCTCGAGCACATTAAGGCGATGAAGGACCACGCGATCCTGGGAAAT ATCGGCCACTTCGACAACGAGATCGACATGGCCGGGCTGGAGCGCTCCGGGGCGACACGG GTCAACGTCAAGCCTCAGGTCGACCTGTGGACCTTTGGCGACACGGGCCGCTCGATCATC GTGCTGTCCGAGGGGCGGCTGCTGAACCTGGGCAATGCCACCGGGCACCCCTCGTTCGTG ATGAGCAACAGCTTCGCTAACCAGACGATCGCCCAGATCGAGCTGTGGACCAAGAACGAC GAGTACGACAACGAGGTGTACCGGCTGCCCAAGCACCTCGACGAGAAGGTGGCTCGAATC CATGTCGAGGCCCTTGGCGGTCACCTGACCAAGCTGACCAAGGAGCAGGCCGAATACCTC GGCGTCGACGTCGAGGGTCCCTACAAGCCGGACCACTACCGCTACTGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P9WGV3 UniProtKB Entry Name SAHH_MYCTU PDB ID(s) 2ZIZ, 2ZJ0, 2ZJ1, 3CE6, 3DHY KEGG ID mtu:Rv3248c NCBI Gene ID 888746 - General References
- Cole ST, Brosch R, Parkhill J, Garnier T, Churcher C, Harris D, Gordon SV, Eiglmeier K, Gas S, Barry CE 3rd, Tekaia F, Badcock K, Basham D, Brown D, Chillingworth T, Connor R, Davies R, Devlin K, Feltwell T, Gentles S, Hamlin N, Holroyd S, Hornsby T, Jagels K, Krogh A, McLean J, Moule S, Murphy L, Oliver K, Osborne J, Quail MA, Rajandream MA, Rogers J, Rutter S, Seeger K, Skelton J, Squares R, Squares S, Sulston JE, Taylor K, Whitehead S, Barrell BG: Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature. 1998 Jun 11;393(6685):537-44. [Article]
- Festa RA, McAllister F, Pearce MJ, Mintseris J, Burns KE, Gygi SP, Darwin KH: Prokaryotic ubiquitin-like protein (Pup) proteome of Mycobacterium tuberculosis [corrected] . PLoS One. 2010 Jan 6;5(1):e8589. doi: 10.1371/journal.pone.0008589. [Article]
- Kelkar DS, Kumar D, Kumar P, Balakrishnan L, Muthusamy B, Yadav AK, Shrivastava P, Marimuthu A, Anand S, Sundaram H, Kingsbury R, Harsha HC, Nair B, Prasad TS, Chauhan DS, Katoch K, Katoch VM, Kumar P, Chaerkady R, Ramachandran S, Dash D, Pandey A: Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry. Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3. [Article]
- Reddy MC, Kuppan G, Shetty ND, Owen JL, Ioerger TR, Sacchettini JC: Crystal structures of Mycobacterium tuberculosis S-adenosyl-L-homocysteine hydrolase in ternary complex with substrate and inhibitors. Protein Sci. 2008 Dec;17(12):2134-44. doi: 10.1110/ps.038125.108. Epub 2008 Sep 24. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details 5'-S-ethyl-5'-thioadenosine experimental unknown target Details