Beta-2-microglobulin

Details

Name
Beta-2-microglobulin
Kind
protein
Synonyms
Not Available
Gene Name
B2M
UniProtKB Entry
P61769Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0012637|Beta-2-microglobulin
MSRSVALAVLALLSLSGLEAIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLL
KNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM
Number of residues
119
Molecular Weight
13714.43
Theoretical pI
6.51
GO Classification
Functions
identical protein binding
Processes
antigen processing and presentation of endogenous peptide antigen via MHC class I / antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent / cellular response to iron ion / negative regulation of receptor binding / positive regulation of ferrous iron binding / positive regulation of protein binding / positive regulation of receptor binding / positive regulation of receptor-mediated endocytosis / positive regulation of T cell cytokine production / positive regulation of T cell mediated cytotoxicity / positive regulation of transferrin receptor binding / protein refolding / T cell differentiation in thymus
Components
early endosome lumen / early endosome membrane / endoplasmic reticulum lumen / ER to Golgi transport vesicle membrane / external side of plasma membrane / extracellular exosome / extracellular region / extracellular space / focal adhesion / Golgi apparatus / Golgi membrane / HFE-transferrin receptor complex / membrane / MHC class I protein complex / phagocytic vesicle membrane / plasma membrane
General Function
Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation (PubMed:25356553)
Specific Function
identical protein binding
Pfam Domain Function
Signal Regions
1-20
Transmembrane Regions
Not Available
Cellular Location
Secreted
Gene sequence
>lcl|BSEQ0012638|Beta-2-microglobulin (B2M)
ATGTCTCGCTCCGTGGCCTTAGCTGTGCTCGCGCTACTCTCTCTTTCTGGCCTGGAGGCT
ATCCAGCGTACTCCAAAGATTCAGGTTTACTCACGTCATCCAGCAGAGAATGGAAAGTCA
AATTTCCTGAATTGCTATGTGTCTGGGTTTCATCCATCCGACATTGAAGTTGACTTACTG
AAGAATGGAGAGAGAATTGAAAAAGTGGAGCATTCAGACTTGTCTTTCAGCAAGGACTGG
TCTTTCTATCTCTTGTACTACACTGAATTCACCCCCACTGAAAAAGATGAGTATGCCTGC
CGTGTGAACCATGTGACTTTGTCACAGCCCAAGATAGTTAAGTGGGATCGAGACATGTAA
Chromosome Location
15
Locus
15q21.1
External Identifiers
ResourceLink
UniProtKB IDP61769
UniProtKB Entry NameB2MG_HUMAN
GenBank Protein ID27763813
GenBank Gene IDAY187687
GeneCard IDB2M
HGNC IDHGNC:914
PDB ID(s)1A1M, 1A1N, 1A1O, 1A6Z, 1A9B, 1A9E, 1AGB, 1AGC, 1AGD, 1AGE, 1AGF, 1AKJ, 1AO7, 1B0G, 1B0R, 1BD2, 1C16, 1CE6, 1CG9, 1DE4, 1DUY, 1DUZ, 1E27, 1E28, 1EEY, 1EEZ, 1EFX, 1EXU, 1GZP, 1GZQ, 1HHG, 1HHH, 1HHI, 1HHJ, 1HHK, 1HLA, 1HSA, 1HSB, 1I1F, 1I1Y, 1I4F, 1I7R, 1I7T, 1I7U, 1IM3, 1IM9, 1JF1, 1JGD, 1JGE, 1JHT, 1JNJ, 1K5N, 1KPR, 1KTL, 1LDS, 1LP9, 1M05, 1M6O, 1MHE, 1MI5, 1N2R, 1OF2, 1OGA, 1OGT, 1ONQ, 1P7Q, 1PY4, 1Q94, 1QEW, 1QLF, 1QQD, 1QR1, 1QRN, 1QSE, 1QSF, 1QVO, 1R3H, 1S8D, 1S9W, 1S9X, 1S9Y, 1SYS, 1SYV, 1T1W, 1T1X, 1T1Y, 1T1Z, 1T20, 1T21, 1T22, 1TMC, 1TVB, 1TVH, 1UQS, 1UXS, 1UXW, 1VGK, 1W0V, 1W0W, 1W72, 1X7Q, 1XH3, 1XR8, 1XR9, 1XZ0, 1YDP, 1YPZ, 1ZHK, 1ZHL, 1ZS8, 1ZSD, 1ZT4, 1ZVS, 2A83, 2AK4, 2AV1, 2AV7, 2AXF, 2AXG, 2BCK, 2BNQ, 2BNR, 2BSR, 2BSS, 2BST, 2BVO, 2BVP, 2BVQ, 2C7U, 2CII, 2CIK, 2CLR, 2D31, 2D4D, 2D4F, 2DYP, 2E8D, 2ESV, 2F53, 2F54, 2F74, 2F8O, 2FYY, 2FZ3, 2GIT, 2GJ6, 2GT9, 2GTW, 2GTZ, 2GUO, 2H26, 2H6P, 2HJK, 2HJL, 2HLA, 2HN7, 2J8U, 2JCC, 2NW3, 2NX5, 2P5E, 2P5W, 2PO6, 2PYE, 2RFX, 2UWE, 2V2W, 2V2X, 2VB5, 2VLJ, 2VLK, 2VLL, 2VLR, 2X4N, 2X4O, 2X4P, 2X4Q, 2X4R, 2X4S, 2X4T, 2X4U, 2X70, 2X89, 2XKS, 2XKU, 2XPG, 2YPK, 2YPL, 2YXF, 2Z9T, 3AM8, 3B3I, 3B6S, 3BGM, 3BH8, 3BH9, 3BHB, 3BO8, 3BP4, 3BP7, 3BVN, 3BW9, 3BWA, 3BXN, 3BZE, 3BZF, 3C9N, 3CDG, 3CII, 3CIQ, 3CZF, 3D18, 3D25, 3D2U, 3D39, 3D3V, 3DBX, 3DHJ, 3DHM, 3DTX, 3DX6, 3DX7, 3DX8, 3DXA, 3EKC, 3FFC, 3FQN, 3FQR, 3FQT, 3FQU, 3FQW, 3FQX, 3FT2, 3FT3, 3FT4, 3GIV, 3GJF, 3GSN, 3GSO, 3GSQ, 3GSR, 3GSU, 3GSV, 3GSW, 3GSX, 3H7B, 3H9H, 3H9S, 3HAE, 3HCV, 3HG1, 3HLA, 3HPJ, 3HUJ, 3I6G, 3I6K, 3I6L, 3IB4, 3IXA, 3JTS, 3KLA, 3KPL, 3KPM, 3KPN, 3KPO, 3KPP, 3KPQ, 3KPR, 3KPS, 3KWW, 3KXF, 3KYN, 3KYO, 3L3D, 3L3G, 3L3I, 3L3J, 3L3K, 3LKN, 3LKO, 3LKP, 3LKQ, 3LKR, 3LKS, 3LN4, 3LN5, 3LOW, 3LOZ, 3LV3, 3M17, 3M1B, 3MGO, 3MGT, 3MR9, 3MRB, 3MRC, 3MRD, 3MRE, 3MRF, 3MRG, 3MRH, 3MRI, 3MRJ, 3MRK, 3MRL, 3MRM, 3MRN, 3MRO, 3MRP, 3MRQ, 3MRR, 3MV7, 3MV8, 3MV9, 3MYJ, 3MYZ, 3MZT, 3NA4, 3NFN, 3O3A, 3O3B, 3O3D, 3O3E, 3O4L, 3OV6, 3OX8, 3OXR, 3OXS, 3PWJ, 3PWL, 3PWN, 3PWP, 3QDA, 3QDG, 3QDJ, 3QDM, 3QEQ, 3QFD, 3QFJ, 3QZW, 3REW, 3RL1, 3RL2, 3RWJ, 3S6C, 3SDX, 3SJV, 3SKM, 3SKO, 3SPV, 3T8X, 3TID, 3TIE, 3TLR, 3TM6, 3TO2, 3TZV, 3U0P, 3UPR, 3UTQ, 3UTS, 3UTT, 3V5D, 3V5H, 3V5K, 3VCL, 3VFM, 3VFN, 3VFO, 3VFP, 3VFR, 3VFS, 3VFT, 3VFU, 3VFV, 3VFW, 3VH8, 3VRI, 3VRJ, 3VWJ, 3VWK, 3VXM, 3VXN, 3VXO, 3VXP, 3VXR, 3VXS, 3VXU, 3W0W, 3W39, 3WL9, 3WLB, 3WUW, 3X11, 3X12, 3X13, 3X14, 4E0K, 4E0L, 4E5X, 4EN3, 4EUP, 4F7M, 4F7P, 4F7T, 4FTV, 4FXL, 4G8G, 4G8I, 4G9D, 4G9F, 4GKN, 4GKS, 4GUP, 4HKJ, 4HWZ, 4HX1, 4I48, 4I4W, 4JFD, 4JFE, 4JFF, 4JFO, 4JFP, 4JFQ, 4JQV, 4JQX, 4JRX, 4JRY, 4K71, 4K7F, 4KDT, 4L29, 4L3C, 4L3E, 4L4T, 4L4V, 4LCW, 4LCY, 4LHU, 4LNR, 4M8V, 4MJ5, 4MJ6, 4MJI, 4MNQ, 4N0F, 4N0U, 4N8V, 4NNX, 4NNY, 4NO0, 4NO2, 4NO3, 4NO5, 4NQC, 4NQD, 4NQE, 4NQV, 4NQX, 4NT6, 4O2C, 4O2E, 4O2F, 4ONO, 4PJ5, 4PJ7, 4PJ8, 4PJ9, 4PJA, 4PJB, 4PJC, 4PJD, 4PJE, 4PJF, 4PJG, 4PJH, 4PJI, 4PJX, 4PR5, 4PRA, 4PRB, 4PRD, 4PRE, 4PRH, 4PRI, 4PRN, 4PRP, 4QOK, 4QRP, 4QRQ, 4QRR, 4QRS, 4QRT, 4QRU, 4R9H, 4RA3, 4RAH, 4RMQ, 4RMR, 4RMS, 4RMT, 4RMU, 4RMV, 4RMW, 4U1H, 4U1I, 4U1J, 4U1K, 4U1L, 4U1M, 4U1N, 4U1S, 4U6X, 4U6Y, 4UQ2, 4UQ3, 4WC8, 4WDI, 4WJ5, 4WO4, 4WU5, 4WU7, 4WUU, 4WW2, 4WWK, 4X0S, 4X6C, 4X6D, 4X6E, 4X6F, 4XXC, 4Z76, 4Z77, 4Z78, 5B38, 5B39, 5BJT, 5BRZ, 5BS0, 5BXF, 5C07, 5C08, 5C09, 5C0A, 5C0B, 5C0C, 5C0D, 5C0E, 5C0F, 5C0G, 5C0I, 5C0J, 5C9J, 5CFH, 5CKA, 5CKG, 5CS7, 5CSB, 5CSG, 5D2L, 5D2N, 5D5M, 5D7I, 5D7J, 5D7L, 5D9S, 5DDH, 5DEF, 5DEG, 5E00, 5E6I, 5E9D, 5ENW, 5EO0, 5EO1, 5EOT, 5EU3, 5EU4, 5EU5, 5EU6, 5EUO, 5F1I, 5F7D, 5F9J, 5FA3, 5FA4, 5FDW, 5GR7, 5GRD, 5GRG, 5GSB, 5GSD, 5GSR, 5GSV, 5GSX, 5HGA, 5HGB, 5HGD, 5HGH, 5HHM, 5HHN, 5HHO, 5HHP, 5HHQ, 5HYJ, 5IB1, 5IB2, 5IB3, 5IB4, 5IB5, 5IEH, 5IEK, 5IM7, 5INC, 5IND, 5IRO, 5ISZ, 5IUE, 5J1A, 5JHD, 5JZI, 5KNM, 5L2J, 5L2K, 5MEN, 5MEO, 5MEP, 5MEQ, 5MER, 5N1Y, 5N6B, 5NHT, 5NME, 5NMF, 5NMG, 5NMH, 5NMK, 5NQ1, 5NQ3, 5NQK, 5OPI, 5SWQ, 5T6W, 5T6X, 5T6Y, 5T6Z, 5T70, 5TEZ, 5TRZ, 5TS1, 5TXS, 5U16, 5U17, 5U1R, 5U2V, 5U6Q, 5U72, 5U98, 5V5L, 5V5M, 5VGD, 5VGE, 5VUD, 5VUE, 5VUF, 5VVP, 5VWD, 5VWF, 5VWH, 5VWJ, 5VZ5, 5W1V, 5W1W, 5W67, 5W69, 5W6A, 5WER, 5WHK, 5WJL, 5WJN, 5WKE, 5WKF, 5WKG, 5WKH, 5WKI, 5WL1, 5WMN, 5WMO, 5WMP, 5WMQ, 5WMR, 5WSH, 5WWI, 5WWJ, 5WWU, 5WXC, 5WXD, 5XOS, 5XOT, 5XOV, 5YXN, 5YXU, 6AEE, 6AM5, 6AMT, 6AMU, 6APN, 6AT5, 6AT9, 6AVF, 6AVG, 6BJ2, 6BJ3, 6BJ8, 6BXP, 6BXQ, 6C09, 6C15, 6C97, 6C98, 6C99, 6CUG, 6D29, 6D2B, 6D2R, 6D2T, 6D64, 6D78, 6DKP, 6EI2, 6ENY, 6EQA, 6EQB, 6EWA, 6EWC, 6EWO, 6FGB, 6G3J, 6G3K, 6GGM, 6GH1, 6GH4, 6GHN, 6GK3, 6GL1, 6ID4, 6IEX, 6ILM, 6J1V, 6J1W, 6J29, 6J2A, 6J2E, 6J2G, 6J2H, 6J2I, 6J2J, 6JOZ, 6JP3, 6JTN, 6JTO, 6JTP, 6K60, 6K7T, 6LA6, 6LA7, 6M1B, 6M24, 6M2J, 6M2K, 6MPP, 6MT3, 6MT4, 6MT5, 6MT6, 6MTL, 6MTM, 6MWR, 6NCA, 6NHA, 6NPR, 6NUX, 6O4Y, 6O4Z, 6O51, 6O53, 6O9B, 6O9C, 6OPD, 6P23, 6P27, 6P2C, 6P2F, 6P2S, 6P64, 6PA1, 6PAG, 6PBH, 6PTB, 6PTE, 6PUC, 6PUD, 6PUE, 6PUF, 6PUG, 6PUH, 6PUI, 6PUJ, 6PUK, 6PUL, 6PUM, 6PVC, 6PVD, 6PYJ, 6PYL, 6PYV, 6PYW, 6PZ5, 6Q3K, 6Q3S, 6QIO, 6QIP, 6R2L, 6RP9, 6RPA, 6RPB, 6RSY, 6SS7, 6SS8, 6SS9, 6SSA, 6TDO, 6TDP, 6TDQ, 6TDR, 6TDS, 6TMO, 6TRN, 6TRO, 6UJ7, 6UJ8, 6UJ9, 6UJO, 6UJQ, 6UK2, 6UK4, 6ULI, 6ULK, 6ULN, 6ULR, 6UON, 6UZ1, 6UZM, 6UZN, 6UZO, 6UZP, 6UZQ, 6UZS, 6V2O, 6V2P, 6V2Q, 6V3J, 6V7Y, 6V7Z, 6V80, 6VB0, 6VB1, 6VB2, 6VB3, 6VB4, 6VB5, 6VB6, 6VB7, 6VIU, 6VM7, 6VM8, 6VM9, 6VMA, 6VMC, 6VMX, 6VPZ, 6VQ2, 6VQD, 6VQE, 6VQO, 6VQY, 6VQZ, 6VR1, 6VR5, 6VRM, 6VRN, 6W51, 6W9U, 6W9V, 6WNA, 6WOL, 6WZY, 6X00, 6XQA, 6XQP, 6Y26, 6Y27, 6Y28, 6Y29, 6Y2A, 6Y2B, 6Z9V, 6Z9W, 6Z9X, 6ZKW, 6ZKX, 6ZKY, 6ZKZ, 7AFV, 7ALO, 7B5F, 7BBG, 7BH8, 7C9V, 7CIQ, 7CIR, 7CIS, 7DUU, 7DYN, 7DZM, 7DZN, 7EDO, 7EJL, 7EJM, 7EJN, 7EU2, 7F4W, 7JWI, 7JYU, 7JYV, 7JYW, 7JYX, 7K80, 7K81, 7KGO, 7KGP, 7KGQ, 7KGR, 7KGS, 7KGT, 7KOZ, 7KP0, 7KP1, 7L1B, 7L1C, 7L1D, 7LFZ, 7LG0, 7LG2, 7LG3, 7LGD, 7LGT, 7LLI, 7LLJ, 7M8S, 7M8T, 7M8U, 7MJ6, 7MJ7, 7MJ8, 7MJ9, 7MJA, 7MKB, 7MLE, 7MX4, 7MXF, 7MXH, 7N1A, 7N1B, 7N1E, 7N1F, 7N2N, 7N2O, 7N2P, 7N2Q, 7N2R, 7N2S, 7N4K, 7N5C, 7N5P, 7N5Q, 7N6D, 7N6E, 7N9J, 7NA5, 7NDQ, 7NDT, 7NDU, 7NMC, 7NMD, 7NME, 7NMF, 7NMG, 7NMO, 7NMR, 7NMT, 7NMV, 7NMY, 7NN5, 7NUI, 7OW3, 7OW4, 7OW5, 7OW6, 7P3D, 7P3E, 7P49, 7P4B, 7PB2, 7PBC, 7PBE, 7PDW, 7PHR, 7Q15, 7Q98, 7Q99, 7Q9A, 7Q9B, 7QNG, 7QPD, 7QPJ, 7R7V, 7R7W, 7R7X, 7R7Y, 7R80, 7RE7, 7RE8, 7RK7, 7RM4, 7RRG, 7RTD, 7RTR, 7RYM, 7RYN, 7RYO, 7RZD, 7RZJ, 7S79, 7S7D, 7S7E, 7S7F, 7S8A, 7S8E, 7S8F, 7S8Q, 7S8R, 7S8S, 7SA2, 7SH4, 7SIF, 7SIG, 7SIH, 7SIS, 7STF, 7SU9, 7T0L, 7T5M, 7TLT, 7TR4, 7TUC, 7TUD, 7TUE, 7U1R, 7U21, 7UC5, 7UFJ, 7UM2, 7UMG, 7UR1, 7WJ2, 7WJ3, 7WKJ, 7WT3, 7WT4, 7WT5, 7WZZ, 7X00, 7X1B, 7X1C, 7XF3, 7YG3, 7ZT2, 7ZT3, 7ZT4, 7ZT5, 7ZT7, 7ZT8, 7ZT9, 7ZUC, 8A7O, 8A7P, 8A7Q, 8A7T, 8BP6, 8CX4, 8DNT, 8DV3, 8DV4, 8DVG, 8E13, 8E2Z, 8E8I, 8EB2, 8EC5, 8EK5, 8ELG, 8ELH, 8EMF, 8EMG, 8EMI, 8EMJ, 8EMK, 8EN8, 8ENH, 8EO8, 8ERX, 8ES8, 8ES9, 8ESA, 8ESH, 8F5A, 8F7M, 8FJA, 8FJB, 8FRT, 8FU4, 8GLE, 8GLF, 8GLG, 8GLH, 8GLI, 8GOM, 8GON, 8GVB, 8GVG, 8GVI, 8HN4, 8I5C, 8I5D, 8I5E, 8IF1, 8ISN, 8QFY, 8RBU, 8RBV, 8RCV, 8REF, 8RH6, 8RHQ, 8RNG, 8RNH, 8ROO, 8ROP, 8SBK, 8SBL, 8SGB, 8SGM, 8SHI, 8SOS, 8TBV, 8TBW, 8TUB, 8TUH, 8U9G, 8WTE, 8WUL
KEGG IDhsa:567
NCBI Gene ID567
General References
  1. Gussow D, Rein R, Ginjaar I, Hochstenbach F, Seemann G, Kottman A, Ploegh HL: The human beta 2-microglobulin gene. Primary structure and definition of the transcriptional unit. J Immunol. 1987 Nov 1;139(9):3132-8. [Article]
  2. He XH, Xu LH, Liu Y, Zeng YY: [Cloning of human beta-microglobulin gene and its high expression in Escherichia coli]. Sheng Wu Gong Cheng Xue Bao. 2004 Jan;20(1):99-103. [Article]
  3. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
  4. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  5. Rosa F, Berissi H, Weissenbach J, Maroteaux L, Fellous M, Revel M: The beta2-microglobulin mRNA in human Daudi cells has a mutated initiation codon but is still inducible by interferon. EMBO J. 1983;2(2):239-43. [Article]
  6. Suggs SV, Wallace RB, Hirose T, Kawashima EH, Itakura K: Use of synthetic oligonucleotides as hybridization probes: isolation of cloned cDNA sequences for human beta 2-microglobulin. Proc Natl Acad Sci U S A. 1981 Nov;78(11):6613-7. [Article]
  7. Cunningham BA, Wang JL, Berggard I, Peterson PA: The complete amino acid sequence of beta 2-microglobulin. Biochemistry. 1973 Nov 20;12(24):4811-22. [Article]
  8. Gorevic PD, Munoz PC, Casey TT, DiRaimondo CR, Stone WJ, Prelli FC, Rodrigues MM, Poulik MD, Frangione B: Polymerization of intact beta 2-microglobulin in tissue causes amyloidosis in patients on chronic hemodialysis. Proc Natl Acad Sci U S A. 1986 Oct;83(20):7908-12. [Article]
  9. Haag-Weber M, Mai B, Horl WH: Isolation of a granulocyte inhibitory protein from uraemic patients with homology of beta 2-microglobulin. Nephrol Dial Transplant. 1994;9(4):382-8. [Article]
  10. Argiles A, Derancourt J, Jauregui-Adell J, Mion C, Demaille JG: Biochemical characterization of serum and urinary beta 2 microglobulin in end-stage renal disease patients. Nephrol Dial Transplant. 1992;7(11):1106-10. [Article]
  11. Azkargorta M, Soria J, Ojeda C, Guzman F, Acera A, Iloro I, Suarez T, Elortza F: Human Basal Tear Peptidome Characterization by CID, HCD, and ETD Followed by in Silico and in Vitro Analyses for Antimicrobial Peptide Identification. J Proteome Res. 2015 Jun 5;14(6):2649-58. doi: 10.1021/acs.jproteome.5b00179. Epub 2015 May 20. [Article]
  12. Momoi T, Suzuki M, Titani K, Hisanaga S, Ogawa H, Saito A: Amino acid sequence of a modified beta 2-microglobulin in renal failure patient urine and long-term dialysis patient blood. Clin Chim Acta. 1995 May 15;236(2):135-44. [Article]
  13. Miyata T, Inagi R, Wada Y, Ueda Y, Iida Y, Takahashi M, Taniguchi N, Maeda K: Glycation of human beta 2-microglobulin in patients with hemodialysis-associated amyloidosis: identification of the glycated sites. Biochemistry. 1994 Oct 11;33(40):12215-21. [Article]
  14. Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Burckstummer T, Bennett KL, Superti-Furga G, Colinge J: Initial characterization of the human central proteome. BMC Syst Biol. 2011 Jan 26;5:17. doi: 10.1186/1752-0509-5-17. [Article]
  15. Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62. doi: 10.1016/j.jprot.2013.11.014. Epub 2013 Nov 22. [Article]
  16. Vaca Jacome AS, Rabilloud T, Schaeffer-Reiss C, Rompais M, Ayoub D, Lane L, Bairoch A, Van Dorsselaer A, Carapito C: N-terminome analysis of the human mitochondrial proteome. Proteomics. 2015 Jul;15(14):2519-24. doi: 10.1002/pmic.201400617. Epub 2015 Jun 8. [Article]
  17. Bjorkman PJ, Saper MA, Samraoui B, Bennett WS, Strominger JL, Wiley DC: Structure of the human class I histocompatibility antigen, HLA-A2. Nature. 1987 Oct 8-14;329(6139):506-12. [Article]
  18. Saper MA, Bjorkman PJ, Wiley DC: Refined structure of the human histocompatibility antigen HLA-A2 at 2.6 A resolution. J Mol Biol. 1991 May 20;219(2):277-319. [Article]
  19. Okon M, Bray P, Vucelic D: 1H NMR assignments and secondary structure of human beta 2-microglobulin in solution. Biochemistry. 1992 Sep 22;31(37):8906-15. [Article]
  20. Collins EJ, Garboczi DN, Karpusas MN, Wiley DC: The three-dimensional structure of a class I major histocompatibility complex molecule missing the alpha 3 domain of the heavy chain. Proc Natl Acad Sci U S A. 1995 Feb 14;92(4):1218-21. [Article]
  21. Smith KJ, Reid SW, Harlos K, McMichael AJ, Stuart DI, Bell JI, Jones EY: Bound water structure and polymorphic amino acids act together to allow the binding of different peptides to MHC class I HLA-B53. Immunity. 1996 Mar;4(3):215-28. [Article]
  22. Trinh CH, Smith DP, Kalverda AP, Phillips SE, Radford SE: Crystal structure of monomeric human beta-2-microglobulin reveals clues to its amyloidogenic properties. Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):9771-6. Epub 2002 Jul 15. [Article]
  23. Stewart-Jones GB, McMichael AJ, Bell JI, Stuart DI, Jones EY: A structural basis for immunodominant human T cell receptor recognition. Nat Immunol. 2003 Jul;4(7):657-63. Epub 2003 Jun 8. [Article]
  24. Kihara M, Chatani E, Iwata K, Yamamoto K, Matsuura T, Nakagawa A, Naiki H, Goto Y: Conformation of amyloid fibrils of beta2-microglobulin probed by tryptophan mutagenesis. J Biol Chem. 2006 Oct 13;281(41):31061-9. Epub 2006 Aug 10. [Article]
  25. Eakin CM, Berman AJ, Miranker AD: A native to amyloidogenic transition regulated by a backbone trigger. Nat Struct Mol Biol. 2006 Mar;13(3):202-8. Epub 2006 Feb 19. [Article]
  26. Iwata K, Matsuura T, Sakurai K, Nakagawa A, Goto Y: High-resolution crystal structure of beta2-microglobulin formed at pH 7.0. J Biochem. 2007 Sep;142(3):413-9. Epub 2007 Jul 23. [Article]
  27. Ricagno S, Colombo M, de Rosa M, Sangiovanni E, Giorgetti S, Raimondi S, Bellotti V, Bolognesi M: DE loop mutations affect beta2-microglobulin stability and amyloid aggregation. Biochem Biophys Res Commun. 2008 Dec 5;377(1):146-50. doi: 10.1016/j.bbrc.2008.09.108. Epub 2008 Oct 1. [Article]
  28. Esposito G, Ricagno S, Corazza A, Rennella E, Gumral D, Mimmi MC, Betto E, Pucillo CE, Fogolari F, Viglino P, Raimondi S, Giorgetti S, Bolognesi B, Merlini G, Stoppini M, Bolognesi M, Bellotti V: The controlling roles of Trp60 and Trp95 in beta2-microglobulin function, folding and amyloid aggregation properties. J Mol Biol. 2008 May 9;378(4):887-97. doi: 10.1016/j.jmb.2008.03.002. Epub 2008 Mar 8. [Article]
  29. Ricagno S, Raimondi S, Giorgetti S, Bellotti V, Bolognesi M: Human beta-2 microglobulin W60V mutant structure: Implications for stability and amyloid aggregation. Biochem Biophys Res Commun. 2009 Mar 13;380(3):543-7. doi: 10.1016/j.bbrc.2009.01.116. Epub 2009 Jan 25. [Article]
  30. Wani MA, Haynes LD, Kim J, Bronson CL, Chaudhury C, Mohanty S, Waldmann TA, Robinson JM, Anderson CL: Familial hypercatabolic hypoproteinemia caused by deficiency of the neonatal Fc receptor, FcRn, due to a mutant beta2-microglobulin gene. Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):5084-9. Epub 2006 Mar 20. [Article]

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
3-Indolebutyric AcidexperimentalunknowntargetDetails
N-FormylmethionineexperimentalunknowntargetDetails
Copperapproved, investigationalunknowntargetDetails
Opiumapproved, illicitnocarrierbinderDetails