Glycylpeptide N-tetradecanoyltransferase 2

BE0003780ProteinHumansNMT2

Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins (PubMed:25255805, PubMed:9506952). It is acted on by 5 drugs in DrugBank.

Gene name
NMT2
UniProtKB entry
O60551Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
498 residues · 56,980 Da
Also known as
2.3.1.97 · Myristoyl-CoA:protein N-myristoyltransferase 2 · NMT 2 · Peptide N-myristoyltransferase 2 · Protein-lysine myristoyltransferase NMT2

Resolves to

Protein
UniProtO60551UniProt nameNMT2_HUMAN
Gene
HGNCHGNC:7858NCBI Gene9397GenBank3005065GeneCardsNMT2
Pharmacology
KEGGhsa:9397
Structure
PDB4C2XPDB6PAUPDB9NDP
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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11+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Glycylpeptide N-tetradecanoyltransferase 2, and which indications are they being tested in?

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