Low molecular weight phosphotyrosine protein phosphatase

BE0003786ProteinHumansACP1

Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates with differences in substrate specificity between isoform 1 and isoform 2. It is acted on by 3 drugs in DrugBank.

Gene name
ACP1
UniProtKB entry
P24666Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
158 residues · 18,042 Da
Also known as
3.1.3.48 · Adipocyte acid phosphatase · LMW-PTP · LMW-PTPase · Low molecular weight cytosolic acid phosphatase

Resolves to

Protein
UniProtP24666UniProt namePPAC_HUMAN
Gene
HGNCHGNC:122NCBI Gene52GenBank179636GeneCardsACP1
Pharmacology
KEGGhsa:52
Structure
PDB1XWWPDB3N8IPDB4Z99
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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1GO termFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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25+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Low molecular weight phosphotyrosine protein phosphatase, how selective are they, and which programs against it are still in active trials?

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