C-Jun-amino-terminal kinase-interacting protein 1

BE0003789ProteinHumansMAPK8IP1

The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. It is acted on by 5 drugs in DrugBank.

Gene name
MAPK8IP1
UniProtKB entry
Q9UQF2Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
711 residues · 77,524 Da
Also known as
IB-1 · IB1 · Islet-brain 1 · JIP-1 · JIP1

Resolves to

Protein
UniProtQ9UQF2UniProt nameJIP1_HUMAN
Gene
HGNCHGNC:6882NCBI Gene9479GenBank4426597GeneCardsMAPK8IP1
Pharmacology
KEGGhsa:9479
Structure
PDB2G01PDB2GMXPDB2H96
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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16GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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18+ReferencesStructured and connected to the statements they support
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Which approved drugs act on C-Jun-amino-terminal kinase-interacting protein 1, how selective are they, and which programs against it are still in active trials?

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