Serine/threonine-protein kinase haspin

BE0003794ProteinHumansHASPIN

Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-3' (H3T3ph) during mitosis. It is acted on by 4 drugs in DrugBank.

Gene name
HASPIN
UniProtKB entry
Q8TF76Swiss-Prot
Cellular location
Nucleus
Residues / weight
798 residues · 88,495 Da
Also known as
2.7.11.1 · Germ cell-specific gene 2 protein · GSG2 · H-haspin · Haploid germ cell-specific nuclear protein kinase

Resolves to

Protein
UniProtQ8TF76UniProt nameHASP_HUMAN
Gene
HGNCHGNC:19682NCBI Gene83903GenBank118421077GeneCardsHASPIN
Pharmacology
IUPHAR/GtoPdb2028KEGGhsa:83903
Structure
PDB2VUWPDB2WB8PDB3DLZ
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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20+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Serine/threonine-protein kinase haspin, and which indications are they being tested in?

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