Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

BE0003810ProteinHumansPPP1CA

Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets (PubMed:28216226, PubMed:30158517, PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670, PubMed:39603239, PubMed:39603240). It is acted on by 3 drugs in DrugBank.

Gene name
PPP1CA
UniProtKB entry
P62136Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
330 residues · 37,512 Da
Also known as
3.1.3.16 · PP-1A · PPP1A

Resolves to

Protein
UniProtP62136UniProt namePP1A_HUMAN
Gene
HGNCHGNC:9281NCBI Gene5499GenBank35451GeneCardsPPP1CA
Pharmacology
IUPHAR/GtoPdb3264KEGGhsa:5499
Structure
PDB3E7APDB3E7BPDB3EGG
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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18GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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36+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Serine/threonine-protein phosphatase PP1-alpha catalytic subunit, how selective are they, and which programs against it are still in active trials?

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