Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

BE0003811ProteinHumansPPP2R2A

Substrate-recognition subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit (PubMed:1849734, PubMed:33108758). It is acted on by 1 drug in DrugBank.

Gene name
PPP2R2A
UniProtKB entry
P63151Swiss-Prot
Residues / weight
447 residues · 51,692 Da
Also known as
B55 · PP2A subunit B isoform alpha · PP2A subunit B isoform B55-alpha · PP2A subunit B isoform PR55-alpha · PP2A subunit B isoform R2-alpha

Resolves to

Protein
UniProtP63151UniProt name2ABA_HUMAN
Gene
HGNCHGNC:9304NCBI Gene5520GenBank190422GeneCardsPPP2R2A
Pharmacology
KEGGhsa:5520
Structure
PDB3DW8PDB8SO0PDB8TTB
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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10+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform, and which indications are they being tested in?

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