Malonyl-CoA-acyl carrier protein transacylase, mitochondrial

BE0003812ProteinHumansMCAT

Catalyzes the transfer of a malonyl moiety from malonyl-CoA to the free thiol group of the phosphopantetheine arm of the mitochondrial ACP protein (NDUFAB1) (PubMed:12882974, PubMed:19549604). It is acted on by 1 drug in DrugBank.

Gene name
MCAT
UniProtKB entry
Q8IVS2Swiss-Prot
Cellular location
Mitochondrion
Residues / weight
390 residues · 42,961 Da
Also known as
[Acyl-carrier-protein] malonyltransferase · 2.3.1.39 · MCT · Mitochondrial malonyl CoA:ACP acyltransferase · Mitochondrial malonyltransferase

Resolves to

Protein
UniProtQ8IVS2UniProt nameFABD_HUMAN
Gene
HGNCHGNC:29622NCBI Gene27349GenBank8574364GeneCardsMCAT
Pharmacology
KEGGhsa:27349
Structure
PDB2C2NPDB8CSPPDB8CSQ
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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9+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Malonyl-CoA-acyl carrier protein transacylase, mitochondrial, and which indications are they being tested in?

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