V-type proton ATPase subunit B, brain isoform

BE0003813ProteinHumansATP6V1B2

Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:33065002). It is acted on by 3 drugs in DrugBank.

Gene name
ATP6V1B2
UniProtKB entry
P21281Swiss-Prot
Cellular location
Apical cell membrane
Residues / weight
511 residues · 56,500 Da
Also known as
ATP6B2 · Endomembrane proton pump 58 kDa subunit · HO57 · V-ATPase subunit B 2 · Vacuolar proton pump subunit B 2

Resolves to

Protein
UniProtP21281UniProt nameVATB2_HUMAN
Gene
HGNCHGNC:854NCBI Gene526GenBank179563GeneCardsATP6V1B2
Pharmacology
IUPHAR/GtoPdb812KEGGhsa:526
Structure
PDB6WLZPDB6WM2PDB6WM3
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
10GO termsFunction, process and component, as structured annotations
Sign in
3Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
18+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on V-type proton ATPase subunit B, brain isoform, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In