Cytochrome b-c1 complex subunit 8

BE0003857ProteinHumansUQCRQ

Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. It is acted on by 8 drugs in DrugBank.

Gene name
UQCRQ
UniProtKB entry
O14949Swiss-Prot
Cellular location
Mitochondrion inner membrane
Residues / weight
82 residues · 9,906 Da
Also known as
Complex III subunit 8 · Complex III subunit VIII · Ubiquinol-cytochrome c reductase complex 9.5 kDa protein · Ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C

Resolves to

Protein
UniProtO14949UniProt nameQCR8_HUMAN
Gene
HGNCHGNC:29594NCBI Gene27089GenBank2605590GeneCardsUQCRQ
Pharmacology
KEGGhsa:27089
Structure
PDB5XTEPDB5XTHPDB5XTI
Drugs

What you can answer from here — as of September 07, 2019

8DrugsApproved to experimental, with action, bond type and pharmacological action
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10GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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13+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Cytochrome b-c1 complex subunit 8, and which indications are they being tested in?

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