Cytochrome b-c1 complex subunit Rieske, mitochondrial

BE0003858ProteinHumansUQCRFS1

Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation (PubMed:31883641). It is acted on by 9 drugs in DrugBank.

Gene name
UQCRFS1
UniProtKB entry
P47985Swiss-Prot
Cellular location
Mitochondrion inner membrane
Residues / weight
274 residues · 29,668 Da
Also known as
7.1.1.8 · Complex III subunit 5 · Cytochrome b-c1 complex subunit 5 · Rieske iron-sulfur protein · Rieske protein UQCRFS1

Resolves to

Protein
UniProtP47985UniProt nameUCRI_HUMAN
Gene
HGNCHGNC:12587NCBI Gene7386GenBank158255704GeneCardsUQCRFS1
Pharmacology
KEGGhsa:7386
Structure
PDB5XTEPDB5XTHPDB5XTI
Drugs

What you can answer from here — as of September 07, 2019

9DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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17+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Cytochrome b-c1 complex subunit Rieske, mitochondrial, and which indications are they being tested in?

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