pH-gated potassium channel KcsA

BE0003864ProteinStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)kcsA

Acts as a pH-gated potassium ion channel; changing the cytosolic pH from 7 to 4 opens the channel. It is acted on by 1 drug in DrugBank.

Gene name
kcsA
UniProtKB entry
P0A333Swiss-Prot
Cellular location
Cell membrane
Residues / weight
160 residues · 17,693 Da
Also known as
skc1

Resolves to

Protein
UniProtP0A333UniProt nameKCSA_STRCO
Gene
NCBI Gene1103098GenBank7799279
Pharmacology
KEGGsco:SCO7660
Structure
PDB1S5HPDB2HFE
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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2+ReferencesStructured and connected to the statements they support
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Which compounds in development act on pH-gated potassium channel KcsA, and which indications are they being tested in?

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