pH-gated potassium channel KcsA

Details

Name
pH-gated potassium channel KcsA
Kind
protein
Synonyms
  • skc1
Gene Name
kcsA
UniProtKB Entry
P0A333Swiss-Prot
Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
NCBI Taxonomy ID
100226
Amino acid sequence
>lcl|BSEQ0017251|pH-gated potassium channel KcsA
MPPMLSGLLARLVKLLLGRHGSALHWRAAGAATVLLVIVLLAGSYLAVLAERGAPGAQLI
TYPRALWWSVETATTVGYGDLYPVTLWGRLVAVVVMVAGITSFGLVTAALATWFVGREQE
RRGHFVRHSEKAAEEAYTRTTRALHERFDRLERMLDDNRR
Number of residues
160
Molecular Weight
17693.465
Theoretical pI
10.66
GO Classification
Functions
voltage-gated potassium channel activity
Processes
potassium ion transmembrane transport
Components
integral component of membrane / voltage-gated potassium channel complex
General Function
Acts as a pH-gated potassium ion channel; changing the cytosolic pH from 7 to 4 opens the channel.
Specific Function
Not Available
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
28-50 88-111
Cellular Location
Cell membrane
Gene sequence
>lcl|BSEQ0017252|pH-gated potassium channel KcsA (kcsA)
ATGCCACCCATGCTGTCCGGTCTTCTGGCCAGATTGGTCAAACTGCTGCTCGGGCGCCAC
GGCAGTGCGCTGCACTGGAGGGCCGCGGGTGCCGCGACGGTCCTCCTGGTGATCGTCCTC
CTCGCGGGCTCGTACTTGGCCGTCCTGGCTGAGCGCGGCGCACCGGGCGCGCAGCTGATC
ACGTATCCGCGGGCGCTGTGGTGGTCCGTGGAGACCGCGACGACCGTCGGCTACGGCGAC
CTGTACCCCGTGACTCTGTGGGGCCGGCTCGTGGCCGTGGTGGTGATGGTCGCCGGGATC
ACCTCCTTCGGTCTGGTGACCGCCGCGCTGGCCACCTGGTTCGTCGGCCGGGAACAAGAG
CGCCGGGGCCACTTCGTGCGCCACTCCGAGAAGGCCGCCGAGGAGGCGTACACGCGGACG
ACCCGGGCGCTGCACGAGCGTTTCGACCGTTTGGAGCGAATGCTCGACGACAACCGCCGG
TGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP0A333
UniProtKB Entry NameKCSA_STRCO
GenBank Protein ID7799279
GenBank Gene IDAL939132
PDB ID(s)1S5H, 2HFE
KEGG IDsco:SCO7660
NCBI Gene ID1103098
General References
  1. Bentley SD, Chater KF, Cerdeno-Tarraga AM, Challis GL, Thomson NR, James KD, Harris DE, Quail MA, Kieser H, Harper D, Bateman A, Brown S, Chandra G, Chen CW, Collins M, Cronin A, Fraser A, Goble A, Hidalgo J, Hornsby T, Howarth S, Huang CH, Kieser T, Larke L, Murphy L, Oliver K, O'Neil S, Rabbinowitsch E, Rajandream MA, Rutherford K, Rutter S, Seeger K, Saunders D, Sharp S, Squares R, Squares S, Taylor K, Warren T, Wietzorrek A, Woodward J, Barrell BG, Parkhill J, Hopwood DA: Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2). Nature. 2002 May 9;417(6885):141-7. [Article]

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
(2S)-2-(BUTYRYLOXY)-3-HYDROXYPROPYL NONANOATEexperimentalunknowntargetDetails