2-aminobenzoylacetyl-CoA thioesterase

BE0003865ProteinPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)pqsE

Required for the biosynthesis of the quorum-sensing signaling molecules 2-heptyl-4(1H)-quinolone (HHQ) and 2-heptyl-3-hydroxy-4(1H)-quinolone (Pseudomonas quinolone signal or PQS), which are important for biofilm formation and virulence. It is acted on by 1 drug in DrugBank.

Gene name
pqsE
UniProtKB entry
P20581Swiss-Prot
Residues / weight
301 residues · 34,306 Da
Also known as
3.1.2.32 · Uncharacterized protein PA1000

Resolves to

Protein
UniProtP20581UniProt namePQSE_PSEAE
Gene
NCBI Gene880721GenBank1196759
Pharmacology
KEGGpae:PA1000
Structure
PDB2Q0IPDB2Q0JPDB2VW8
Drugs

What you can answer from here — as of May 03, 2025

1DrugApproved to experimental, with action, bond type and pharmacological action
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1GO termFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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3+ReferencesStructured and connected to the statements they support
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Which compounds in development act on 2-aminobenzoylacetyl-CoA thioesterase, and which indications are they being tested in?

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