DNA polymerase I

BE0003871ProteinGeobacillus stearothermophiluspolA

In addition to polymerase activity, the recombinant enzyme has strand displacement and 5'-3' exonuclease activity, but lacks proofreading 3'-5' exonuclease activity. It is acted on by 1 drug in DrugBank.

Gene name
polA
UniProtKB entry
P52026Swiss-Prot
Cellular location
Cytoplasmic
Residues / weight
876 residues · 98,669 Da
Also known as
2.7.7.7 · pol · POL I

Resolves to

Protein
UniProtP52026UniProt nameDPO1_GEOSE
Gene
GenBank755588
Structure
PDB1L3SPDB1L3TPDB1L3U
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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5+ReferencesStructured and connected to the statements they support
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Which compounds in development act on DNA polymerase I, and which indications are they being tested in?

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