Peptide deformylase 2
Details
- Name
- Peptide deformylase 2
- Kind
- protein
- Synonyms
- 3.5.1.88
- PDF 2
- Polypeptide deformylase 2
- Gene Name
- def2
- UniProtKB Entry
- Q819K2Swiss-Prot
- Organism
- Bacillus cereus (strain ATCC 14579 / DSM 31 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NRRL B-3711)
- NCBI Taxonomy ID
- 226900
- Amino acid sequence
>lcl|BSEQ0012702|Peptide deformylase 2 MLTMKDVIREGDPILRNVAEEVSLPASEEDTTTLKEMIEFVINSQDPEMAEKYSLRPGIG LAAPQIGVSKKMIAVHVTDADGTLYSHALFNPKIISHSVERTYLQGGEGCLSVDREVPGY VPRYTRITVKATSINGEEVKLRLKGLPAIVFQHEIDHLNGVMFYDHINKENPFAAPDDSK PLER
- Number of residues
- 184
- Molecular Weight
- 20474.205
- Theoretical pI
- 5.1
- GO Classification
- Functionsiron ion binding / peptide deformylase activityProcessestranslation
- General Function
- Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
- Specific Function
- metal ion binding
- Pfam Domain Function
- Pep_deformylase (PF01327)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasmic
- Gene sequence
>lcl|BSEQ0012703|Peptide deformylase 2 (def2) ATGCTTACAATGAAAGATGTTATTCGCGAAGGAGATCCTATTTTGCGCAACGTTGCAGAA GAGGTGTCCTTACCGGCAAGCGAAGAAGATACAACTACCTTAAAAGAAATGATTGAATTC GTAATAAATAGCCAAGATCCTGAAATGGCTGAAAAATATAGTTTACGCCCTGGAATCGGA TTAGCGGCTCCGCAAATCGGTGTTTCAAAAAAAATGATTGCAGTTCATGTAACCGATGCG GATGGTACATTATATAGCCATGCATTATTCAATCCAAAAATCATTAGCCATTCTGTTGAA CGTACATATTTACAGGGTGGTGAAGGCTGTCTATCTGTAGACCGCGAAGTACCTGGTTAT GTTCCTCGTTATACAAGAATTACAGTAAAAGCAACTTCTATTAACGGAGAAGAAGTAAAA TTACGTTTAAAAGGTTTACCAGCAATCGTATTTCAGCACGAGATTGACCATTTAAATGGC GTTATGTTCTATGACCATATCAATAAAGAAAATCCTTTTGCCGCTCCTGATGATTCCAAA CCTCTAGAGCGATAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q819K2 UniProtKB Entry Name DEF2_BACCR GenBank Protein ID 29893819 GenBank Gene ID AE016877 PDB ID(s) 2OKL KEGG ID bce:BC3974 NCBI Gene ID 1206319 - General References
- Ivanova N, Sorokin A, Anderson I, Galleron N, Candelon B, Kapatral V, Bhattacharyya A, Reznik G, Mikhailova N, Lapidus A, Chu L, Mazur M, Goltsman E, Larsen N, D'Souza M, Walunas T, Grechkin Y, Pusch G, Haselkorn R, Fonstein M, Ehrlich SD, Overbeek R, Kyrpides N: Genome sequence of Bacillus cereus and comparative analysis with Bacillus anthracis. Nature. 2003 May 1;423(6935):87-91. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details 2-[(Formyl-Hydroxy-Amino)-Methyl]-Heptanoic Acid [1-(2-Hydroxymethyl-Pyrrolidine-1-Carbonyl)-2-Methyl-Propyl]-Amide experimental unknown target Details