Peptide deformylase

Details

Name
Peptide deformylase
Kind
protein
Synonyms
  • 3.5.1.88
  • PDF
  • Polypeptide deformylase
Gene Name
def
UniProtKB Entry
P68771Swiss-Prot
Organism
Streptococcus pyogenes serotype M1
NCBI Taxonomy ID
301447
Amino acid sequence
>lcl|BSEQ0017256|Peptide deformylase
MSAQDKLIKPSHLITMDDIIREGNPTLRAVAKEVSLPLCDEDILLGEKMMQFLKHSQDPV
MAEKLGLRAGVGLAAPQIDVSKRIIAVLVPNLPDKEGNPPKEAYSWQEVLYNPKIVSHSV
QDAALSDGEGCLSVDRVVEGYVVRHARVTVDYYDKEGQQHRIKLKGYNAIVVQHEIDHIN
GVLFYDRINAKNPFETKEELLILD
Number of residues
204
Molecular Weight
22862.095
Theoretical pI
5.6
GO Classification
Functions
iron ion binding / peptide deformylase activity
Processes
translation
General Function
Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
Specific Function
metal ion binding
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Cytoplasmic
Gene sequence
>lcl|BSEQ0017257|Peptide deformylase (def)
ATGTCTGCACAAGATAAATTAATTAAACCTAGTCATCTGATTACCATGGATGACATTATT
CGTGAAGGGAATCCAACTTTAAGAGCTGTCGCCAAAGAAGTGAGCTTACCCTTGTGTGAT
GAGGATATCCTATTAGGAGAAAAGATGATGCAATTTTTGAAGCATTCTCAAGATCCTGTA
ATGGCGGAAAAACTTGGTCTTAGGGCCGGTGTTGGTCTAGCAGCTCCTCAGATTGATGTG
TCAAAACGTATCATCGCTGTGCTCGTTCCTAATCTTCCTGATAAAGAAGGAAATCCTCCT
AAAGAAGCCTATAGCTGGCAAGAAGTCCTGTATAATCCTAAAATCGTTTCTCATTCTGTT
CAAGATGCAGCCCTTTCTGATGGCGAAGGTTGTTTATCTGTCGATCGTGTTGTTGAAGGG
TATGTGGTTCGCCATGCTCGTGTTACAGTAGACTACTATGATAAAGAAGGACAACAGCAT
CGCATCAAATTAAAGGGATACAACGCTATTGTGGTTCAACATGAAATTGACCATATCAAT
GGTGTTTTGTTCTACGATCGGATCAATGCTAAAAACCCCTTTGAAACCAAAGAAGAGCTC
TTGATTTTAGACTAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP68771
UniProtKB Entry NameDEF_STRP1
GenBank Protein ID13621326
GenBank Gene IDAE004092
PDB ID(s)2OS3
KEGG IDspy:SPy_1958
NCBI Gene ID901633
General References
  1. Ferretti JJ, McShan WM, Ajdic D, Savic DJ, Savic G, Lyon K, Primeaux C, Sezate S, Suvorov AN, Kenton S, Lai HS, Lin SP, Qian Y, Jia HG, Najar FZ, Ren Q, Zhu H, Song L, White J, Yuan X, Clifton SW, Roe BA, McLaughlin R: Complete genome sequence of an M1 strain of Streptococcus pyogenes. Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4658-63. [Article]
  2. Sumby P, Porcella SF, Madrigal AG, Barbian KD, Virtaneva K, Ricklefs SM, Sturdevant DE, Graham MR, Vuopio-Varkila J, Hoe NP, Musser JM: Evolutionary origin and emergence of a highly successful clone of serotype M1 group a Streptococcus involved multiple horizontal gene transfer events. J Infect Dis. 2005 Sep 1;192(5):771-82. Epub 2005 Jul 29. [Article]

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
2-[(Formyl-Hydroxy-Amino)-Methyl]-Heptanoic Acid [1-(2-Hydroxymethyl-Pyrrolidine-1-Carbonyl)-2-Methyl-Propyl]-AmideexperimentalunknowntargetDetails