Peptide deformylase
Details
- Name
- Peptide deformylase
- Kind
- protein
- Synonyms
- 3.5.1.88
- Polypeptide deformylase
- Gene Name
- def
- UniProtKB Entry
- P68771Swiss-Prot
- Organism
- Streptococcus pyogenes serotype M1
- NCBI Taxonomy ID
- 301447
- Amino acid sequence
>lcl|BSEQ0017256|Peptide deformylase MSAQDKLIKPSHLITMDDIIREGNPTLRAVAKEVSLPLCDEDILLGEKMMQFLKHSQDPV MAEKLGLRAGVGLAAPQIDVSKRIIAVLVPNLPDKEGNPPKEAYSWQEVLYNPKIVSHSV QDAALSDGEGCLSVDRVVEGYVVRHARVTVDYYDKEGQQHRIKLKGYNAIVVQHEIDHIN GVLFYDRINAKNPFETKEELLILD
- Number of residues
- 204
- Molecular Weight
- 22862.095
- Theoretical pI
- 5.6
- GO Classification
- Functionsiron ion binding / peptide deformylase activityProcessestranslation
- General Function
- Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
- Specific Function
- metal ion binding
- Pfam Domain Function
- Pep_deformylase (PF01327)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasmic
- Gene sequence
>lcl|BSEQ0017257|Peptide deformylase (def) ATGTCTGCACAAGATAAATTAATTAAACCTAGTCATCTGATTACCATGGATGACATTATT CGTGAAGGGAATCCAACTTTAAGAGCTGTCGCCAAAGAAGTGAGCTTACCCTTGTGTGAT GAGGATATCCTATTAGGAGAAAAGATGATGCAATTTTTGAAGCATTCTCAAGATCCTGTA ATGGCGGAAAAACTTGGTCTTAGGGCCGGTGTTGGTCTAGCAGCTCCTCAGATTGATGTG TCAAAACGTATCATCGCTGTGCTCGTTCCTAATCTTCCTGATAAAGAAGGAAATCCTCCT AAAGAAGCCTATAGCTGGCAAGAAGTCCTGTATAATCCTAAAATCGTTTCTCATTCTGTT CAAGATGCAGCCCTTTCTGATGGCGAAGGTTGTTTATCTGTCGATCGTGTTGTTGAAGGG TATGTGGTTCGCCATGCTCGTGTTACAGTAGACTACTATGATAAAGAAGGACAACAGCAT CGCATCAAATTAAAGGGATACAACGCTATTGTGGTTCAACATGAAATTGACCATATCAAT GGTGTTTTGTTCTACGATCGGATCAATGCTAAAAACCCCTTTGAAACCAAAGAAGAGCTC TTGATTTTAGACTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P68771 UniProtKB Entry Name DEF_STRP1 GenBank Protein ID 13621326 GenBank Gene ID AE004092 PDB ID(s) 2OS3 KEGG ID spy:SPy_1958 NCBI Gene ID 901633 - General References
- Ferretti JJ, McShan WM, Ajdic D, Savic DJ, Savic G, Lyon K, Primeaux C, Sezate S, Suvorov AN, Kenton S, Lai HS, Lin SP, Qian Y, Jia HG, Najar FZ, Ren Q, Zhu H, Song L, White J, Yuan X, Clifton SW, Roe BA, McLaughlin R: Complete genome sequence of an M1 strain of Streptococcus pyogenes. Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4658-63. [Article]
- Sumby P, Porcella SF, Madrigal AG, Barbian KD, Virtaneva K, Ricklefs SM, Sturdevant DE, Graham MR, Vuopio-Varkila J, Hoe NP, Musser JM: Evolutionary origin and emergence of a highly successful clone of serotype M1 group a Streptococcus involved multiple horizontal gene transfer events. J Infect Dis. 2005 Sep 1;192(5):771-82. Epub 2005 Jul 29. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details 2-[(Formyl-Hydroxy-Amino)-Methyl]-Heptanoic Acid [1-(2-Hydroxymethyl-Pyrrolidine-1-Carbonyl)-2-Methyl-Propyl]-Amide experimental unknown target Details