3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ

Details

Name
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ
Kind
protein
Synonyms
  • (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase
  • (3R)-hydroxymyristoyl-ACP dehydrase
  • 4.2.1.59
  • Beta-hydroxyacyl-ACP dehydratase
Gene Name
fabZ
UniProtKB Entry
O25928Swiss-Prot
Organism
Helicobacter pylori (strain ATCC 700392 / 26695)
NCBI Taxonomy ID
85962
Amino acid sequence
>lcl|BSEQ0012707|3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ
MEQSHQNLQSQFFIEHILQILPHRYPMLLVDRIIELQANKKIVAYKNITFNEDVFNGHFP
NKPIFPGVLIVEGMAQTGGFLAFTSLWGFDPEIAKTKIVYFMTIDKVKFRIPVTPGDRLE
YHLEVLKHKGMIWQVGGTAQVDGKVVAEAELKAMIAERD
Number of residues
159
Molecular Weight
18196.17
Theoretical pI
7.18
GO Classification
Functions
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Processes
fatty acid biosynthetic process / lipid A biosynthetic process
Components
cytoplasm
General Function
Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
Specific Function
(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0012708|3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ (fabZ)
ATGGAACAAAGCCATCAAAACTTGCAATCTCAATTTTTTATAGAGCATATCTTACAAATT
CTACCTCACCGCTATCCCATGCTTTTAGTGGATAGAATTATAGAGTTACAAGCCAATAAA
AAAATTGTCGCTTATAAGAATATCACTTTTAATGAAGACGTGTTTAACGGGCATTTCCCT
AATAAGCCCATTTTCCCGGGCGTTTTGATCGTAGAGGGCATGGCGCAAACGGGAGGGTTT
TTAGCCTTCACTAGCTTGTGGGGGTTTGACCCTGAAATCGCCAAAACAAAAATCGTGTAT
TTCATGACGATTGATAAGGTTAAATTCCGCATCCCTGTAACCCCAGGCGACAGATTAGAA
TACCATTTAGAAGTCTTAAAGCATAAGGGCATGATCTGGCAAGTGGGTGGCACGGCTCAA
GTGGATGGCAAAGTGGTCGCTGAAGCCGAATTGAAAGCCATGATTGCAGAGAGAGATTAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDO25928
UniProtKB Entry NameFABZ_HELPY
GenBank Protein ID2313078
GenBank Gene IDAE000511
PDB ID(s)2GLL, 2GLM, 2GLP, 2GLV
KEGG IDheo:C694_07100
NCBI Gene ID900307
General References
  1. Tomb JF, White O, Kerlavage AR, Clayton RA, Sutton GG, Fleischmann RD, Ketchum KA, Klenk HP, Gill S, Dougherty BA, Nelson K, Quackenbush J, Zhou L, Kirkness EF, Peterson S, Loftus B, Richardson D, Dodson R, Khalak HG, Glodek A, McKenney K, Fitzegerald LM, Lee N, Adams MD, Hickey EK, Berg DE, Gocayne JD, Utterback TR, Peterson JD, Kelley JM, Cotton MD, Weidman JM, Fujii C, Bowman C, Watthey L, Wallin E, Hayes WS, Borodovsky M, Karp PD, Smith HO, Fraser CM, Venter JC: The complete genome sequence of the gastric pathogen Helicobacter pylori. Nature. 1997 Aug 7;388(6642):539-47. [Article]

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
N'-[(1E)-(3,5-DIBROMO-2,4-DIHYDROXYPHENYL)METHYLENE]NICOTINOHYDRAZIDEexperimentalunknowntargetDetails